Hepatotropic viral infection associated systemic vasculitides-hepatitis B virus associated polyarteritis nodosa and hepatitis C virus associated cryoglobulinemic vasculitis

Journal of Clinical and Experimental Hepatology
Aman Sharma, Kusum Sharma

Abstract

Two hepatotropic viruses have been shown to have causal relationship with systemic vasculitis-hepatitis B with classical polyarteritis nodosa and hepatitis C with cryoglobulinemic vasculitis. The present paper provides an updated overview on the clinical presentations and management of these vasculitides. HBV associated PAN patients have higher weight loss, peripheral neuropathy, mononeuritis multiplex, abdominal pain, gastrointestinal manifestations requiring surgery, cardiomyopathy, orchitis, hypertension, and/or elevated transaminase levels. Microaneurysms are also more common in mesenteric artery. Skin manifestations, however are less common. These patients also have a severe disease as suggested by higher five factor score and higher BVAS. Though relapses are less common, mortality is higher in patients with HBV PAN as compared to non HBV PAN. Plasmapheresis has a role in treatment in clearing off immune complexes. The common clinical manifestations of HCV associated cryoglobulinemic vasculitis are skin lesions, peripheral neuropathy, glomerulonephritis, arthritis, and sicca symptoms. Though combination therapy comprising of pegylated interferon α and ribavirin is the first line of management, immunotherapy is needed for s...Continue Reading

Citations

Dec 19, 2016·International Journal of Rheumatic Diseases·Aman SharmaSurjit Singh
Jun 28, 2018·Rheumatology International·Resat OzarasFehmi Tabak
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Warren L Kupin
Jan 29, 2021·World Journal of Gastroenterology : WJG·Chrong-Reen Wang, Hung-Wen Tsai
Mar 18, 2021·Zeitschrift für Gastroenterologie·Florian Gunnar ScurtChristos Chatzikyrkou
Apr 28, 2021·Rheumatology International·Gsrsnk NaiduAman Sharma

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