Hepcidin and ferritin levels in restless legs syndrome: a case-control study.

Scientific Reports
Sofiene CheniniYves Dauvilliers

Abstract

The association between restless legs syndrome (RLS) and iron homeostasis remains unclear. We compared serum hepcidin and ferritin levels in patients with RLS and controls, and assessed their relationships with RLS phenotype, drug intake, and history of augmentation syndrome. 102 drug-free RLS patients (age 58.9 [24.5-77.2], 63 females) and 73 controls (age 56.8 [23.46-76.6], 45 females) underwent a polysomnography recording. Hepcidin levels were quantified by ELISA. 34 RLS patients had a second assessment after starting dopaminergic drugs. Ferritin level was low (< 50 µg/l) in 14.7% of patients and 25% of controls, with no between-group differences in the mean values. Hepcidin levels were higher in patients even after adjustment for confounding factors, and excluding participants with low ferritin levels. Ferritin and hepcidin levels were comparable before and after treatment, and between patients with (n = 17) and without history of augmentation. Ferritin and hepcidin levels correlated with age, body mass index, and periodic leg movements. Higher hepcidin levels were associated with older age, older age at RLS onset, less daytime sleepiness and familial RLS. In conclusion, serum hepcidin levels but not ferritin were higher in...Continue Reading

References

May 30, 1974·The New England Journal of Medicine·D A LipschitzC A Finch
Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·J MontplaisirP Lespérance
Jun 16, 2005·Archives of Internal Medicine·Richard P AllenLuigi Ferini-Strambi
Aug 28, 2007·Experimental Biology and Medicine·Jerome L Sullivan
Jul 7, 2010·Cell·Matthias W HentzeClara Camaschella
Oct 13, 2011·Clinical Chemistry·Joyce J C KrootDorine W Swinkels
Sep 21, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin Wagner, Damien Ashby
Sep 21, 2013·Current Opinion in Pulmonary Medicine·Yves Dauvilliers, Juliane Winkelmann
Jul 15, 2015·BMC Genetics·Tessel E GaleslootSita H Vermeulen
Apr 6, 2016·Blood·Domenico GirelliDorine W Swinkels
Jan 7, 2017·Sleep Medicine·James R ConnorRichard P Allen
Feb 9, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Yves DauvilliersSylvain Lehmann
Jul 30, 2018·Revue neurologique·S Leu-SemenescuY Dauvilliers
Sep 25, 2018·Lancet Neurology·Claudia TrenkwalderJuliane Winkelmann

❮ Previous
Next ❯

Citations

Jul 9, 2021·Nature and Science of Sleep·Stefania MondelloRaffaele Ferri
Nov 5, 2021·Nature Reviews. Disease Primers·Mauro ManconiYves Dauvilliers

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.