Hepcidin and Iron Metabolism in Pregnancy: Correlation with Smoking and Birth Weight and Length

Biological Trace Element Research
Magdalena ChełchowskaMariusz Ołtarzewski

Abstract

To estimate the effect of tobacco smoking on iron homeostasis and the possible association between hepcidin and the neonatal birth weight and length, concentrations of serum hepcidin and selected iron markers were measured in 81 healthy pregnant women (41 smokers and 40 nonsmokers). The smoking mothers had significantly lower concentrations of serum hepcidin (p < 0.001), iron (p < 0.001), and hemoglobin (p < 0.05), but higher erythropoietin (p < 0.05) levels compared with non-smoking pregnant women. Logistic regression analysis showed the highest negative impact of the number of cigarettes smoked per day (β = -0.46; p < 0.01) and positive impact of ferritin level (β = 0.47; p < 0.001) on serum hepcidin concentration. The birth weight and the body length of smoking mothers' infants were significantly lower than in tobacco abstinent group (p < 0.001). In multiple regression analysis, birth body weight (β = 0.56; p < 0.001) and length (β = 0.50; p < 0.001) were significantly related to maternal hepcidin values. Tobacco smoking affected hepcidin level in serum of pregnant women in a dose-dependent manner. Low concentrations of iron and hemoglobin in maternal serum coexisting with high level of erythropoietin suggest that smoking co...Continue Reading

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Citations

Nov 5, 2016·Clinical Nutrition Research·Hyungjo KimInkyung Baik
Nov 12, 2016·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Lauren WelkeLisa Tussing-Humphreys
Jun 15, 2019·International Journal of Environmental Research and Public Health·Magdalena ChełchowskaJadwiga Ambroszkiewicz
Mar 28, 2017·Biological Trace Element Research·Jadwiga AmbroszkiewiczMagdalena Chełchowska
May 15, 2021·The Proceedings of the Nutrition Society·Mairead E KielyÁine Hennessy

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Methods Mentioned

BETA
ELISA
cesarean section

Software Mentioned

STATISTICA

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