Hepcidin concentrations and iron homeostasis in preeclampsia

Clinical Chemistry and Laboratory Medicine : CCLM
Gergely ToldiBarna Vásárhelyi

Abstract

Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This is in contrast to inflammation characteristic for PE. The link between iron homeostasis and inflammation is hepcidin. Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE. We obtained peripheral blood samples from 30 preeclamptic [gestational age: 36.5 (24-40) weeks] and 37 healthy pregnant women [gestational age: 36 (28-39) weeks] to determine plasma hepcidin and interleukin-6 (IL-6) concentrations, complete blood cell counts and parameters of iron homeostasis [plasma iron, transferrin and ferritin levels and total iron binding capacity (TIBC)]. Hepcidin was measured using mass spectrophotometry. The Mann-Whitney test was used for statistical analysis. Plasma hepcidin, IL-6, iron and ferritin concentrations were increased (p<0.05 for all), whereas plasma transferrin, TIBC and mean corpuscular hemoglobin concentrations were lower (p<0.05 for all) in PE compared to healthy pregnant women. No differences were seen in the other parameters investigated. Plasma iron concentrations are increased despite high hepcidin concentrations in PE. This might indicate a resistance to the iron-decreasing action...Continue Reading

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Citations

Jul 5, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Gergely ToldiGabriella Bekõ
Nov 9, 2011·Nutrition Reviews·Fernando E Viteri
Jun 20, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Serap SimavliNilgun Turhan
Dec 31, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Candan Iltemir DuvanCemile Koca
Aug 6, 2014·Nutrients·Mary Dawn KoenigElizabeta Nemeth
Jul 8, 2011·The Journal of Obstetrics and Gynaecology Research·Béla GyarmatiZoltán Takáts
Nov 19, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·S G NilaSajini Elizabeth Jacob
Feb 23, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nila Shaji GeethaSajini E Jacob
Dec 5, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Asuman Akkaya FıratEmel Ulakoğlu Zengin
Dec 18, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Susanne van SantenDorine W Swinkels
Mar 27, 2018·Biological Reviews of the Cambridge Philosophical Society·Douglas B Kell, Etheresia Pretorius
Jun 17, 2020·Blood·Lara KämmererSamira Lakhal-Littleton
May 16, 2019·Annual Review of Nutrition·Michael K GeorgieffSarah E Cusick
Mar 12, 2019·Journal of Pregnancy·Alejandra María Gómez-GutiérrezJulio Cesar Bueno-Sánchez
Dec 12, 2020·Pharmaceuticals·Joel MintzKyle Bauckman

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