Hepcidin expression and iron transport in alveolar macrophages

American Journal of Physiology. Lung Cellular and Molecular Physiology
Ngoc-Bich H NguyenFunmei Yang

Abstract

Alveolar macrophages express many proteins important in iron homeostasis, including the iron importer divalent metal transport 1 (DMT1) and the iron exporter ferroportin 1 (FPN1) that likely participate in lung defense. We found the iron regulatory hormone hepcidin (HAMP) is also produced by alveolar macrophages. In mouse alveolar macrophages, HAMP mRNA was detected at a low level when not stimulated but at a high level when exposed to lipopolysaccharide (LPS). LPS also affected the mRNA levels of the iron transporters, with DMT1 being upregulated and FPN1 downregulated. However, iron had no effect on HAMP expression but was able to upregulate both DMT1 and FPN1 in alveolar macrophages. IL-1 and IL-6, which are important in HAMP augmentation in hepatocytes, also did not affect HAMP expression in alveolar macrophages. In fact, the LPS-induced alterations in the expression of HAMP as well as DMT1 and FPN1 were preserved in the alveolar macrophages isolated from IL-1 receptor or IL-6-deficient mice. When alveolar macrophages were loaded with transferrin-bound (55)Fe, the subsequent release of (55)Fe was inhibited significantly by LPS. In addition, treatment of these cells with either LPS or HAMP caused the diminishment of the surf...Continue Reading

References

Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·H NakamuraA Ishizaka
Nov 1, 1995·American Journal of Respiratory and Critical Care Medicine·R FinkelsteinM G Cosio
Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·L J WesseliusB S Skikne
Apr 15, 1996·The Journal of Clinical Investigation·J WilbornM Peters-Golden
Aug 1, 1997·Nature Genetics·J V Gray, K J Johnson
Dec 24, 1997·Environmental Health Perspectives·C A GoldsmithL Kobzik
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·M D FlemingN C Andrews
Apr 5, 2000·The Journal of Biological Chemistry·S Abboud, D J Haile
Feb 24, 2001·Nature·M KristiansenS K Moestrup
Mar 23, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M Dörger, F Krombach
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·G NicolasS Vaulont
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gaël NicolasSophie Vaulont
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xinchao WangClaude A Piantadosi
May 25, 2002·Inhalation Toxicology·Neil E AlexisAndrew J Ghio
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Funmei YangAndrew J Ghio
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Funmei YangAndrew J Ghio
Jul 2, 2003·Pflügers Archiv : European journal of physiology·Andrew T McKie, David J Barlow
Sep 27, 2003·American Journal of Respiratory Cell and Molecular Biology·Daniel A CulverMary Jane Thomassen
Nov 8, 2003·Blood·Dan-Qing LouSophie Vaulont
Feb 6, 2004·Blood Cells, Molecules & Diseases·Antonello Pietrangelo
Mar 17, 2004·Free Radical Biology & Medicine·Jennifer L TuriAndrew J Ghio
Apr 17, 2004·American Journal of Respiratory and Critical Care Medicine·Borja G CosíoIan M Adcock
Aug 18, 2004·Current Opinion in Hematology·Tomas Ganz
Jan 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mitchell D KnutsonMarianne Wessling-Resnick
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Pauline LeeErnest Beutler
Mar 8, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Funmei YangAndrew J Ghio
May 24, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrew J GhioLaura M Garrick
Jun 4, 2005·Blood Cells, Molecules & Diseases·Xiao-Bing LiuDavid J Haile
Aug 2, 2005·Cell Metabolism·Adriana DonovanNancy C Andrews
Aug 6, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·François Canonne-HergauxPhilippe Gros
Oct 4, 2005·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Junki InamuraYutaka Kohgo

❮ Previous
Next ❯

Citations

Dec 17, 2010·Immunologic Research·Bobby J Cherayil
Apr 23, 2013·Trends in Parasitology·Susanne van SantenAndré J A M van der Ven
Jan 15, 2013·Antioxidants & Redox Signaling·Bernhard BrüneAndreas Weigert
Dec 17, 2009·Hematology·An-Sheng Zhang, Caroline A Enns
Aug 4, 2011·Respiratory Research·Marie D FrazierJennifer L Turi
Jun 30, 2012·PloS One·Karolina BenesovaMartina U Muckenthaler
May 21, 2009·Haematologica·Pavle MatakPaul A Sharp
Aug 7, 2013·Nutrients·Andrea U Steinbicker, Martina U Muckenthaler
Oct 22, 2008·The Journal of Nutrition·James F CollinsMitchell D Knutson
Sep 30, 2014·The Journal of Infection·Femke A M Jonker, Michaël Boele van Hensbroek
Sep 17, 2014·The Annals of Occupational Hygiene·Swaantje CasjensBeate Pesch
Mar 26, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Funmei YangAndrew J Ghio
Apr 5, 2013·Biotechnology Letters·Yaghoub YazdaniAbbas Rezaei
Mar 25, 2014·Journal of Clinical Laboratory Analysis·Triantafyllia SdogouLydia Kossiva
Feb 5, 2013·Seminars in Immunology·S RecalcatiG Cairo
Apr 17, 2012·Blood Cells, Molecules & Diseases·Abitha SukumaranMolly Jacob
Mar 28, 2012·Autoimmunity Reviews·Stefania RecalcatiGaetano Cairo
Apr 1, 2009·Fish & Shellfish Immunology·Makoto InamiJan H W M Rombout
Apr 7, 2009·Biochimica Et Biophysica Acta·Michael D Garrick, Laura M Garrick
Jul 24, 2012·The Journal of Nutritional Biochemistry·Elmar AignerWolfgang Patsch
Sep 13, 2008·Biochimica Et Biophysica Acta·Günter Weiss
Nov 21, 2007·Microbes and Infection·Mathieu F CellierCarole Campion
Dec 30, 2009·European Journal of Immunology·Stefania RecalcatiGaetano Cairo
Jun 6, 2015·Experimental Physiology·Gisela GiorgiMarta Elena Roque
Mar 10, 2015·Hematology·Liliana BârsanGabriel Mircescu
Apr 7, 2015·Biochimica Et Biophysica Acta·Bruno Silva, Paula Faustino
May 6, 2014·Frontiers in Pharmacology·Tania Veuthey, Marianne Wessling-Resnick
Aug 21, 2015·PLoS Pathogens·Kathryn MichelsBorna Mehrad
May 13, 2017·The International Journal of Biochemistry & Cell Biology·Md Khadem AliJay C Horvat
Mar 3, 2015·World Journal of Hepatology·Elmar AignerChristian Datz
Jun 10, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gautam Rishi, V Nathan Subramaniam
Mar 3, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Jing Jing LiYun Zhang
Dec 25, 2009·Circulation. Cardiovascular Genetics·Jerome L Sullivan
Sep 3, 2011·PloS One·Valeria SantiniMaria Domenica Cappellini
Jul 13, 2013·The Journal of Biological Chemistry·Michael Li-Hsuan HuangDes R Richardson
Sep 3, 2013·Expert Review of Hematology·Wei-Na KongYan-Zhong Chang
Jan 31, 2014·Journal of Clinical Laboratory Analysis·Fernando OliveiraRúben Fernandes
May 18, 2018·PloS One·Rafiou AgoroCatherine Mura
Oct 19, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Adelaide TovarSamir N P Kelada
Oct 13, 2011·Clinical Chemistry·Joyce J C KrootDorine W Swinkels

❮ Previous
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