Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis

Journal of the American Society of Nephrology : JASN
Yogesh ScindiaSundararaman Swaminathan

Abstract

Iron-mediated oxidative stress is implicated in the pathogenesis of renal ischemia-reperfusion injury. Hepcidin is an endogenous acute phase hepatic hormone that prevents iron export from cells by inducing degradation of the only known iron export protein, ferroportin. In this study, we used a mouse model to investigate the effect of renal ischemia-reperfusion injury on systemic iron homeostasis and determine if dynamic modulation of iron homeostasis with hepcidin has therapeutic benefit in the treatment of AKI. Renal ischemia-reperfusion injury induced hepatosplenic iron export through increased ferroportin expression, which resulted in hepatosplenic iron depletion and an increase in serum and kidney nonheme iron levels. Exogenous hepcidin treatment prevented renal ischemia-reperfusion-induced changes in iron homeostasis. Hepcidin also decreased kidney ferroportin expression and increased the expression of cytoprotective H-ferritin. Hepcidin-induced restoration of iron homeostasis was accompanied by a significant reduction in ischemia-reperfusion-induced tubular injury, apoptosis, renal oxidative stress, and inflammatory cell infiltration. Hepcidin -: deficient mice demonstrated increased susceptibility to ischemia-reperfusion...Continue Reading

References

Nov 1, 1992·The Journal of Clinical Investigation·A VoogdJ F Koster
Jun 22, 1991·Proceedings. Biological Sciences·E R BaumingerA Treffry
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L L MillerF M Torti
Apr 1, 1982·Prostaglandins, Leukotrienes, and Medicine·A K Mandal, J Miller
Dec 1, 1994·Free Radical Biology & Medicine·M S Paller, B E Hedlund
Apr 5, 2000·The Journal of Biological Chemistry·S Abboud, D J Haile
Dec 13, 2000·The Journal of Biological Chemistry·C H ParkT Ganz
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Chuanyu Li, Robert M Jackson
Aug 6, 2002·The Journal of Biological Chemistry·Funmei YangDavid J Haile
Jul 10, 2003·The Journal of Surgical Research·Akihiko HirakawaTakaya Tanaka
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Pierre C DagherBruce A Molitoris
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P O BerberatM P Soares
Nov 25, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hong HuangAbdulla K Salahudeen
Jul 16, 2004·Kidney International·John J Friedewald, Hamid Rabb
Sep 2, 2004·Journal of the American Society of Nephrology : JASN·Jonathan Himmelfarb The PICARD Group
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Jaya MishraPrasad Devarajan
Apr 1, 2005·Current Opinion in Pediatrics·Prasad Devarajan
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Chiang-Ting ChienLai Ming-Kuen
Jun 24, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John A GossSamuel Wyllie
Sep 30, 2005·Journal of the American Society of Nephrology : JASN·Mariusz L KielarChristopher Y Lu
Apr 1, 2006·Blood·Jeanne-Claire Lesbordes-BrionSophie Vaulont
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa J Burne-TaneyHamid Rabb
Jul 13, 2006·Blood·Diedra M Wrighting, Nancy C Andrews
Nov 2, 2006·Current Opinion in Critical Care·Sean M Bagshaw
May 4, 2007·Molecular Biology of the Cell·Ivana De DomenicoJerry Kaplan
Jul 4, 2007·The Journal of Clinical Investigation·Ivana De DomenicoJerry Kaplan
Mar 14, 2008·Journal of the American Society of Nephrology : JASN·Yael Nechemia-ArbelyJonathan H Axelrod
Sep 20, 2008·Nephron. Experimental Nephrology·Gilbert R KinseyMark D Okusa
Dec 19, 2008·American Journal of Physiology. Renal Physiology·Huan Ling LiangVani Nilakantan
Jan 30, 2009·Kidney International·Fereshteh GolabManoocher Soleimani
Feb 26, 2010·Mediators of Inflammation·Ali AkcayCharles L Edelstein
May 7, 2010·American Journal of Physiology. Renal Physiology·Volker H Haase
May 28, 2010·Kidney International·Markus P SchneiderJennifer S Pollock
Jun 9, 2010·Hemoglobin·Nikolaos ArkadopoulosVassilios Smyrniotis
Jun 10, 2010·The Journal of Clinical Investigation·Ivana De DomenicoJerry Kaplan
May 13, 2011·Kidney International·Andrea Havasi, Steven C Borkan
Sep 3, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Julie HoClaudio Rigatto
Oct 12, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Asma ArounCharareh Pourzand

❮ Previous
Next ❯

Citations

Oct 21, 2015·Metallomics : Integrated Biometal Science·Frank Thévenod, Natascha A Wolff
Apr 18, 2016·Seminars in Nephrology·Vyvyca J Walker, Anupam Agarwal
Apr 14, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Jennifer R CharltonKevin M Bennett
Sep 2, 2016·Magnetic Resonance Imaging·Sundararaman Swaminathan
Sep 16, 2016·Journal of the American Society of Nephrology : JASN·Sun-Sang J SungMark D Okusa
Feb 14, 2017·Annual Review of Physiology·Sarah C Huen, Lloyd G Cantley
Mar 16, 2017·Hemodialysis International·Som Dev, Jodie L Babitt
Jul 26, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Merhan Mamdouh Ragy, Neven Makram Aziz
Jun 7, 2018·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Bassem RefaatShakir Idris
May 12, 2018·Cell Death & Disease·Rachel P L van SwelmDorine W Swinkels
Feb 6, 2018·Canadian Journal of Kidney Health and Disease·Nora ChoiJulie Ho
Jun 21, 2018·American Journal of Physiology. Renal Physiology·Xueqiao WangAndong Qiu
Jan 31, 2016·Journal of the American Society of Nephrology : JASN·Rachel P L van SwelmDorine W Swinkels
Feb 10, 2019·Journal of the American Society of Nephrology : JASN·David E LeafSushrut S Waikar
Jul 15, 2015·Nature Reviews. Immunology·Tomas Ganz, Elizabeta Nemeth
Dec 29, 2015·Critical Care : the Official Journal of the Critical Care Forum·Chih-Chung ShiaoUNKNOWN National Taiwan University Hospital Study Group on Acute Renal Failure (NSARF) and the Taiwan Consortium for Acute Kidney In
Nov 19, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·S G NilaSajini Elizabeth Jacob
Feb 23, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nila Shaji GeethaSajini E Jacob
Aug 29, 2019·Nature Reviews. Nephrology·Kristof Van AvondtSacha Zeerleder
Jun 21, 2018·Frontiers in Immunology·Estefanía Tarifeño-SaldiviaSebastian Boltana
Jun 27, 2019·Pharmaceuticals·József BallaAbolfazl Zarjou
Dec 18, 2019·International Journal of Molecular Sciences·Lu ZhangZhibo Gai
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Frank ThévenodMichael D Garrick
Mar 22, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Atilla BayraktarEser Öz Oyar
Jun 18, 2019·Metallomics : Integrated Biometal Science·Joseph IschiaOneel Patel
Sep 27, 2019·Nature Reviews. Nephrology·Rachel P L van SwelmDorine W Swinkels
Jun 4, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mari KurokawaShouichi Ohga
Sep 11, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joanna Sophia J VinkeMartin H de Borst
Sep 26, 2020·Frontiers in Medicine·Vikram SabapathyRahul Sharma
Mar 7, 2020·International Journal of Preventive Medicine·Hassan Ahmadvand, Sina Mahdavifard
Aug 4, 2020·Experimental Biology and Medicine·Chandrashekar AnnamalaiPragasam Viswanathan
Sep 27, 2019·Journal of the American Society of Nephrology : JASN·Shreyak Sharma, David E Leaf
Jun 28, 2019·Frontiers in Pharmacology·Yogesh ScindiaSundararaman Swaminathan
May 4, 2017·Immunological Reviews·Wulf Tonnus, Andreas Linkermann
Jan 25, 2021·Free Radical Biology & Medicine·Qinjie LiuJianan Ren
Feb 7, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard A ZagerRenibus Therapeutics
Dec 4, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Leilismara SousaLeandro A Barbosa
Feb 5, 2021·Signal Transduction and Targeted Therapy·Hong-Fa YanPeng Lei
May 24, 2020·Kidney International·Yogesh ScindiaSundararaman Swaminathan
Apr 19, 2020·Seminars in Nephrology·Kayla McCullough, Subhashini Bolisetty
Apr 30, 2021·Frontiers in Medicine·Ewa WlazloYogesh Scindia
May 20, 2021·Oxidative Medicine and Cellular Longevity·Jingyu WangLi Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Bryan D MalikenKris V Kowdley
Journal of the American Society of Nephrology : JASN
Ali AkcayCharles L Edelstein
© 2021 Meta ULC. All rights reserved