Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study

Journal of Intensive Care
Edward LittonAustralian and New Zealand Intensive Care Society Clinical Trials Group

Abstract

Both anaemia and red blood cell (RBC) transfusion are common and associated with adverse outcomes in patients admitted to the intensive care unit (ICU). The aim of this study was to determine whether serum hepcidin concentration, measured early after ICU admission in patients with anaemia, could identify a group in whom intravenous (IV) iron therapy decreased the subsequent RBC transfusion requirement. We conducted a prospective observational study nested within a multicenter randomized controlled trial (RCT) of IV iron versus placebo. The study was conducted in the ICUs of four tertiary hospitals in Perth, Western Australia. Critically ill patients with haemoglobin (Hb) of < 100 g/L and within 48 h of admission to the ICU were eligible for participation after enrolment in the IRONMAN RCT. The response to IV iron therapy compared with placebo was assessed according to tertile of hepcidin concentration. Hepcidin concentration was measured within 48 h of ICU admission in 133 patients. For patients in the lower two tertiles of hepcidin concentration (< 53.0 μg), IV iron therapy compared with placebo was associated with a significant decrease in RBC transfusion requirement [risk ratio 0.48 (95% CI 0.26-0.85), p = 0.013]. In critica...Continue Reading

References

Sep 24, 2002·JAMA : the Journal of the American Medical Association·Jean Louis VincentUNKNOWN ABC (Anemia and Blood Transfusion in Critical Care) Investigators
Mar 10, 2010·Intensive Care Medicine·Sigismond LasockiPhilippe Montravers
Jan 25, 2011·Anesthesiology·Sigismond LasockiCarole Beaumont
Oct 6, 2011·Annals of Intensive Care·Christophe Lelubre, Jean-Louis Vincent
Jan 28, 2012·American Journal of Respiratory and Critical Care Medicine·Shailaja J HaydenErik R Swenson
Mar 5, 2016·Critical Care Medicine·Frank TackePavel Strnad
Apr 6, 2016·Blood·Domenico GirelliDorine W Swinkels
Nov 2, 2016·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marius van RijnsoeverJohn K Olynyk
Oct 21, 2016·Intensive Care Medicine·UNKNOWN IRONMAN InvestigatorsUNKNOWN Australian and New Zealand Intensive Care Society Clinical Trials Group
Dec 17, 2017·Journal of Cardiothoracic and Vascular Anesthesia·Jolene LimEdward Litton

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Citations

Dec 20, 2019·Scientific Reports·Martin K MeadJoel P A Gummer
Mar 10, 2019·Critical Care : the Official Journal of the Critical Care Forum·Edward Litton, Jolene Lim
Feb 27, 2021·Health Technology Assessment : HTA·Toby RichardsAndrew Klein

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Clinical Trials Mentioned

NCT02276690

Software Mentioned

IRONMAN
LOWESS
Stata

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Edward LittonAustralian and New Zealand Intensive Care Society Clinical Trials Group
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