Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain

The Journal of Nutrition
Ruiwei JiangHuijun Chen

Abstract

Iron accumulation in the central nervous system (CNS) is a common feature of many neurodegenerative diseases. Multicopper ferroxidases (MCFs) play an important role in cellular iron metabolism. However, the role of MCFs in the CNS in health and disease remains poorly characterized. The aim was to study the role of hephaestin (HEPH) and ceruloplasmin (CP) in CNS iron metabolism and homeostasis. Iron concentrations and L-ferritin protein levels of selected brain regions were determined in global hephaestin knockout (Heph KO), global ceruloplasmin knockout (Cp KO), and wild-type (WT) male mice at 6-7 mo of age. Gene expression of divalent metal transporter 1 (Dmt1), ferroportin 1 (Fpn1), Heph, Cp, and transferrin receptor 1 (Tfrc) and HEPH protein level was quantitated in the same brain regions. Iron and L-ferritin protein levels were significantly increased in Heph KO mouse brain cortex (iron: 30%, P < 0.05; L-ferritin: 200%, P < 0.05), hippocampus (iron: 80%, P < 0.05; L-ferritin: 300%, P < 0.05), brainstem (iron: 20%, P < 0.05; L-ferritin: 150%, P < 0.05), and cerebellum (iron: 20%, P < 0.05; L-ferritin: 100%, P < 0.05) regions than in WT and Cp KO mouse brain regions at 6 mo of age. Expression of the Heph gene was significantl...Continue Reading

References

Dec 1, 1990·Journal of Neuroscience Research·J R ConnorE J Mufson
Sep 1, 1989·The American Journal of Clinical Nutrition·S Yehuda, M B Youdim
Feb 1, 1970·British Journal of Haematology·P H PinkertonJ A Edwards
Feb 4, 1966·Science·R M Bannerman, R G Cooper
Nov 1, 1967·British Journal of Haematology·R M Bannerman, P H Pinkerton
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z L HarrisJ D Gitlin
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z L HarrisJ D Gitlin
Dec 23, 1999·The New England Journal of Medicine·N C Andrews
Feb 24, 2001·Molecular Aspects of Medicine·P T LieuY Yang
Jun 11, 2002·Annual Review of Nutrition·Nathan E Hellman, Jonathan D Gitlin
Apr 4, 2003·The Journal of Nutrition·John BeardByron C Jones
Apr 24, 2004·Annals of the New York Academy of Sciences·Prem Ponka
Oct 22, 2004·Nature Reviews. Neuroscience·Luigi ZeccaRobert R Crichton
Nov 6, 2004·Blood Cells, Molecules & Diseases·Srujana CherukuriPaul L Fox
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·Tracey A Rouault, Wing-Hang Tong
Jul 20, 2006·Nature Chemical Biology·Tracey A Rouault
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suh Young Jeong, Samuel David
Mar 11, 2008·Investigative Ophthalmology & Visual Science·Majda HadziahmetovicJoshua L Dunaief
Mar 31, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Huijun ChenChris D Vulpe
Jul 26, 2011·Biochimica Et Biophysica Acta·Hyman M Schipper
Aug 25, 2011·Journal of Molecular Neuroscience : MN·Madhavi Latha Yadav BangaruQuinn H Hogan
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katrin SchulzSamuel David
Feb 22, 2012·The American Journal of Pathology·Natalie WolkowJoshua L Dunaief
Apr 17, 2012·Biochemical and Biophysical Research Communications·Seung-Min LeeChris D Vulpe
Jun 26, 2012·Nucleic Acids Research·Andreas UntergasserSteven G Rozen
Jul 4, 2013·Nature Reviews. Neuroscience·Tracey A Rouault

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Citations

Jan 29, 2016·Journal of Toxicology and Environmental Health. Part a·Sergio CrovellaVioletta Borelli
Oct 7, 2015·Cell Metabolism·Hal DrakesmithTomas Ganz
Jul 28, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Kari A Duck, James R Connor
Dec 20, 2016·Scientific Reports·Bo JiangHuijun Chen
Jun 14, 2019·Biological Reviews of the Cambridge Philosophical Society·Zhong-Ming Qian, Ya Ke
May 9, 2018·Current Neuropharmacology·Bo Wang, Xiao-Ping Wang
Nov 13, 2019·Reviews in the Neurosciences·Thomas BerryAhmed A Moustafa
Nov 22, 2019·Reviews in the Neurosciences·Thomas BerryAhmed A Moustafa
Sep 29, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Moussa KenawiOlivier Loréal
Apr 9, 2017·Molecular Genetics and Genomics : MGG·Cassie L AlburyLyn R Griffiths
Apr 27, 2019·Frontiers in Neuroscience·Giacomo MarchiDomenico Girelli
Mar 30, 2018·Frontiers in Aging Neuroscience·Azhaar AshrafPo-Wah So
Sep 8, 2017·PloS One·Chandrika N DeshpandeMika Jormakka
Nov 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qiong WuYan-Zhong Chang
Feb 20, 2021·Frontiers in Genetics·Xiangzhen WeiLifang Jin
Apr 24, 2018·Biochimica Et Biophysica Acta. General Subjects·Xudong WangBing Zhou
May 1, 2021·Biomedicines·Nina Horn, Pernilla Wittung-Stafshede
Dec 24, 2020·Critical Reviews in Food Science and Nutrition·Magdalena OgłuszkaRafał Radosław Starzyński
Dec 28, 2018·ACS Chemical Neuroscience·Lei-Lei ChenJunxia Xie

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