PMID: 6396652Nov 1, 1984Paper

Hepoxilin, a new family of insulin secretagogues formed by intact rat pancreatic islets

Prostaglandins, Leukotrienes, and Medicine
C R Pace-Asciak, J M Martin

Abstract

Isolated Krebs perifused rat pancreatic islets in the presence of 10 mM glucose convert 12S-HPETE into two hydroxy-epoxides, 8H-11,12-EPETE and 10H-11,12-EPETE for which we propose the name Hepoxilin A and B respectively. Hepoxilin A was investigated for its capacity to release insulin by this preparation. Insulin secretion by these cells, measured in the perifusate by radioimmunoassay, was dependent on the glucose concentration in the perifusing medium. Hepoxilin A dose dependently enhanced further the release of insulin during glucose (10 mM) stimulation (120 +/- 51% at 0.5 x 10(-6) M (n = 3) and 282 +/- 58% at 2.1 x 10(-6) M (n = 3) above control). These results suggest that Hepoxilin A (and possibly also Hepoxilin B) could be the active intermediate(s) involved in the potentiation of glucose dependent insulin secretion by both arachidonic acid and 12-HPETE.

References

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Citations

Jun 9, 2001·Biochemical and Biophysical Research Communications·D ReynaudC R Pace-Asciak
Apr 3, 2009·Archives of Toxicology·Martina DeckerAnnette Cronin
Oct 19, 2011·Cancer Metastasis Reviews·Cecil R Pace-Asciak
Feb 12, 1986·Biochimica Et Biophysica Acta·C R Pace-AsciakS P Speilberg
Oct 30, 1992·Biochimica Et Biophysica Acta·S Yamamoto
Nov 17, 1994·Biochimica Et Biophysica Acta·C R Pace-Asciak
Sep 11, 1989·Brain Research·P L CarlenC R Pace-Asciak
Jan 1, 1986·Progress in Lipid Research·C R Pace-AsciakE J Corey
Jan 1, 1988·Progress in Lipid Research·A A SpectorS A Moore
Jul 1, 1993·General Pharmacology·C R Pace-Asciak
Oct 1, 1995·Journal of Lipid Mediators and Cell Signalling·T Yoshimoto, S Yamamoto
Oct 1, 1995·Journal of Lipid Mediators and Cell Signalling·C R Pace-AsciakP Demin
Jan 1, 1996·Journal of Lipid Mediators and Cell Signalling·P M DeminC R Pace-Asciak
Jan 22, 2000·Biochemical Pharmacology·M SutherlandS Nigam
Nov 26, 2003·Progress in Lipid Research·Arthur A SpectorNeal L Weintraub
Mar 1, 1997·Progress in Lipid Research·S YamamotoN Ueda
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C R Pace-AsciakP L Carlen
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A MargalitA A Livne
Feb 1, 1992·British Journal of Pharmacology·O LaneuvilleC R Pace-Asciak
Nov 1, 1992·British Journal of Pharmacology·O LaneuvilleC R Pace-Asciak
Jun 16, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Yuttana ChawengsubWilliam B Campbell
Jan 11, 2011·Journal of Lipid Research·Annette CroninMichael Arand
Sep 12, 2013·Biochimica Et Biophysica Acta·Agustí Muñoz-GarciaAlan R Brash
Jun 11, 1986·Biochimica Et Biophysica Acta·C R Pace-AsciakS P Spielberg
Nov 24, 1999·FEBS Letters·C R Pace-AsciakG Liu
Apr 30, 1985·Biochemical and Biophysical Research Communications·C R Pace-AsciakW G Su
Jul 5, 2007·The FEBS Journal·Santosh NigamRenate Roux-Van der Merwe
Aug 14, 2003·Biochemical and Biophysical Research Communications·Konkal-Matt R PrasadJerry L Nadler
May 9, 2006·Progress in Lipid Research·Hartmut Kühn, Valerie B O'Donnell
Oct 4, 2005·Biochemical and Biophysical Research Communications·Santosh Nigam, Maria-Patapia Zafiriou
Aug 17, 2005·Biochemical and Biophysical Research Communications·Xiang LiCecil R Pace-Asciak
Aug 30, 1991·Biochemical and Biophysical Research Communications·Z LinC R Pace-Asciak
Dec 31, 1990·Biochemical and Biophysical Research Communications·C R Pace-AsciakE J Corey
May 9, 2009·British Journal of Pharmacology·Cecil R Pace-Asciak

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