Abstract
Circulating microparticles (MPs) are novel potential biomarkers in cancer patients. Their role in hepatocellular carcinoma (HCC) is under intensive investigation. In this study, we tested the hypothesis that MPs expressing the antigen HepPar1 are increased in the blood of subjects with HCC and may serve as markers of early recurrence after liver resection (LR). We studied 15 patients affected by HCC undergoing LR, and used flow cytometry to assess the number of circulating HepPar1+ MPs. Ten subjects without HCC (five with liver cirrhosis and five with healthy livers) were used as controls. After LR, HCC patients underwent a follow-up to check for early recurrence, which occurred in seven cases. The number of circulating HepPar1+ MPs was significantly higher in subjects affected by HCC, compared to individuals without cancer (p < 0.01). We also found that, among HCC patients, the number of circulating HepPar1+ MPs, measured before LR, was significantly higher in those who displayed early recurrence compared to those without recurrence (p = 0.02). Of note, other types of circulating MPs, such as those derived from endothelial cells (CD144+) or those produced by the activated endothelium (CD144+/CD62+), were not associated with HC...Continue Reading
References
Jul 27, 2004·Annals of Surgery·Daniel DindoPierre-Alain Clavien
May 27, 2005·Seminars in Liver Disease·Josep M LlovetVincenzo Mazzaferro
Apr 28, 2006·Journal of Gastroenterology and Hepatology·Jeong Hwan KimJong Chul Rhee
Jun 20, 2006·Acta Cytologica·Luoquan WangKathie Schlesinger
Aug 17, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Chien-Hung ChenSheng-Nan Lu
Jan 2, 2007·Annals of Surgery·Ming ShiJin-Qing Li
May 22, 2008·World Journal of Surgery·Li ZhouQiang Qu
Jun 16, 2009·Gastroenterology·Sasan RoayaieMyron E Schwartz
Sep 28, 2010·Journal of Surgical Oncology·Masaki KaiboriA-Hon Kwon
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jun 30, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Annette S H GouwMasamichi Kojiro
Dec 14, 2011·Journal of Surgical Oncology·Tsung-Han WuMiin-Fu Chen
Dec 20, 2011·American Journal of Surgery·Liguo LiuHaitao Zhao
Mar 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MalvezziE Negri
Mar 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·UNKNOWN European Association for Study of Liver, UNKNOWN European Organisation for Research and Treatment of Cancer
Jun 16, 2012·World Journal of Surgical Oncology·Toshiya KamiyamaAkinobu Taketomi
Jun 23, 2012·Annals of Surgical Oncology·Alessandro CucchettiAntonio D Pinna
Nov 15, 2012·Annals of Surgical Oncology·Manuel Rodríguez-PerálvarezAndrew Kenneth Burroughs
Jun 19, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luigi BolondiPierluigi Toniutto
Aug 6, 2013·Journal of Gastrointestinal Cancer·Felice GiulianteBrian I Carr
Jan 21, 2014·Cancer Biomarkers : Section a of Disease Markers·Wenjie WangShenghua Jie
Feb 5, 2014·Nature Reviews. Gastroenterology & Hepatology·Sara LemoinnePierre-Emmanuel Rautou
May 31, 2014·World Journal of Gastroenterology : WJG·Antonio ColecchiaDavide Festi
Sep 18, 2015·World Journal of Gastroenterology : WJG·Yu-Cheng ZhangYa-Li Wang
May 30, 2016·Thrombosis Research·Elena CampelloPaolo Simioni
Oct 13, 2016·World Journal of Gastroenterology : WJG·Carrie R WongJoseph K Lim
Mar 8, 2017·Journal of Hepatology·Henrike Julich-HaertelMiroslaw Kornek
Citations
May 24, 2020·Journal of Clinical Medicine·Tudor MocanMiroslaw Kornek
Aug 1, 2020·International Journal of Molecular Sciences·Kerstin MenckClaudia Binder
Aug 28, 2020·Frontiers in Medicine·Irma Garcia-MartinezAngela M Valverde
Oct 22, 2020·Cancers·Artur SłomkaMiroslaw Kornek
Feb 23, 2020·Biochimica Et Biophysica Acta. General Subjects·Cristina ZivkoPaola Luciani
Jul 19, 2020·Journal of Hepatology·Sara Thietart, Pierre-Emmanuel Rautou
Apr 14, 2021·Science China. Life Sciences·Xuewei QiHongyang Wang
Apr 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Cong HeZhongdang Xiao