Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model.

International Journal of Cancer. Journal International Du Cancer
Jiangyong MiaoSandra Orsulic

Abstract

Hepsin is a serine protease that is widely expressed in different tissues and cell types, most prominently in the normal liver and kidney. Overexpression of hepsin has been associated with prostate cancers, ovarian cancers and renal cell carcinomas. The physiological functions of hepsin in normal tissues and tumors are poorly understood. To gain insight into its function in ovarian cancer, we analyzed the expression and subcellular localization of hepsin protein in ovarian cancer cell lines and tumors. We showed that the membrane-associated hepsin protein is present at desmosomal junctions, where it colocalizes with its putative proteolytic substrate hepatocyte growth factor. Consistent with the growing evidence that desmosomal junctions and their constituents play a role in cancer progression, we demonstrated that overexpression of hepsin promotes ovarian tumor growth in a mouse model. The ability of ectopic hepsin to induce tumor growth in mice is abrogated by the mutation of 3 critical residues in the catalytic domain, thus implicating the enzymatic activity of hepsin in promoting tumor progression.

References

Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L F AppelJ Fristrom
Jun 25, 1993·Biochimica Et Biophysica Acta·D FarleyH Nick
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Torres-RosadoK Kurachi
Apr 1, 1993·Cell Structure and Function·M WatabeM Takeichi
Jan 4, 1997·Biochimica Et Biophysica Acta·A ZhukovM Ingelman-Sundberg
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·K J Green, C A Gaudry
Aug 24, 2001·Nature·S M DhanasekaranA M Chinnaiyan
Jan 5, 2002·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·S K LoftusW J Pavan
Feb 5, 2004·British Journal of Cancer·T R AdibC Boshoff
Jul 3, 2004·Nature Reviews. Molecular Cell Biology·Julius J JeffersonRonald K H Liem
Aug 25, 2004·Cancer Cell·Olga KlezovitchValeri Vasioukhin
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Lynne Chang, Robert D Goldman
Jan 4, 2005·Biochimica Et Biophysica Acta·Yang LiShi-Hsiang Shen
Nov 18, 2006·Cell·Gaorav P Gupta, Joan Massagué
Jul 11, 2007·The American Journal of Pathology·Michel GuipponiHamish S Scott

❮ Previous
Next ❯

Citations

Aug 7, 2012·Bulletin of Experimental Biology and Medicine·A A RaevskayaM P Kirpichnikov
May 7, 2013·Cell Death and Differentiation·M C GozoS Orsulic
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Johanna I PartanenJuha Klefström
Jun 3, 2009·The Journal of Biological Chemistry·Thomas H BuggeQingyu Wu
Sep 26, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Johanna I PartanenJuha Klefström
Aug 3, 2010·Biochemistry. Biokhimii︠a︡·A A RaevskayaS E Severin
Oct 16, 2010·Cancer Research·Chad A HallScott Goode
Apr 17, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yu-Chen HsuShu-Wha Lin
May 29, 2010·The Biochemical Journal·Toni M AntalisSarah Netzel-Arnett
Feb 5, 2014·Critical Reviews in Clinical Laboratory Sciences·Julia DornViktor Magdolen
Nov 15, 2016·Scientific Reports·Mingming ZhangJianxin Gu
Apr 15, 2016·Biological Chemistry·Andrew S MurrayKarin List
Apr 5, 2019·Future Medicinal Chemistry·Vishnu C Damalanka, James W Janetka
Mar 19, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hala S El-RebeyKarim El Deeb
Nov 17, 2009·Molecular and Cellular Biochemistry·Mengqian ChenKarl X Chai
Nov 22, 2016·The FEBS Journal·Lauren M Tanabe, Karin List
Nov 18, 2018·Journal of Cellular Biochemistry·Jun-Feng Huo, Xiao-Bing Chen
Dec 21, 2018·Journal of Medicinal Chemistry·Vishnu C DamalankaJames W Janetka
Sep 14, 2021·EMBO Reports·Denis BelitškinJuha Klefström

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver International : Official Journal of the International Association for the Study of the Liver
Chien-Hung ChenJin-Chuan Sheu
© 2022 Meta ULC. All rights reserved