Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model.

The Prostate
Srinivas NandanaRobert J Matusik

Abstract

Hepsin is a cell surface protease that is over-expressed in more than 90% of human prostate cancer cases. The previously developed Probasin-hepsin/Large Probasin-T antigen (PB-hepsin/LPB-Tag) bigenic mouse model of prostate cancer demonstrates that hepsin promotes primary tumors that are a mixture of adenocarcinoma and neuroendocrine (NE) lesions, and metastases that are NE in nature. However, since the majority of human prostate tumors are adenocarcinomas, the contribution of hepsin in the progression of adenocarcinoma requires further investigation. We crossed the PB-hepsin mice with PB-Hi-myc transgenic mouse model of prostate adenocarcinoma and characterized the tumor progression in the resulting PB-hepsin/PB-Hi-myc bigenic mice. We report that PB-hepsin/PB-Hi-myc bigenic mice develop invasive adenocarcinoma at 4.5 months. Further, histological analysis of the 12- to 17-month-old mice revealed that the PB-hepsin/PB-Hi-myc model develops a higher grade adenocarcinoma compared with age-matched tumors expressing only PB-Hi-myc. Consistent with targeting hepsin to the prostate, the PB-hepsin/PB-Hi-myc tumors showed higher hepsin expression as compared to the age-matched myc tumors. Furthermore, endogenous expression of hepsin i...Continue Reading

References

Oct 1, 1990·British Journal of Urology·R J CohenD Afrika
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·C CapellaG Klöppel
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N M GreenbergJ M Rosen
Oct 1, 1995·Current Opinion in Cell Biology·H Birkedal-Hansen
Jan 1, 1997·Annual Review of Physiology·H A ChapmanG P Shi
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·C WeiJ G Frelinger
Jun 23, 1999·Oncogene·C E NesbitE V Prochownik
Aug 24, 2001·Nature·S M DhanasekaranA M Chinnaiyan
Jun 28, 2002·Cancer Cell·Dinesh SinghWilliam R Sellers
Mar 12, 2003·The Journal of Urology·Zuxiong ChenThomas A Stamey
Oct 3, 2003·Cancer Cell·Katharine Ellwood-YenCharles L Sawyers
Dec 11, 2003·The Journal of Urology·Carsten StephanEleftherios P Diamandis
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David J Grignon
Aug 25, 2004·Cancer Cell·Olga KlezovitchValeri Vasioukhin
Dec 21, 2004·International Journal of Cancer. Journal International Du Cancer·Kelly A LandersRobert A Gardiner
Jun 16, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Qingyu Wu, Gordon Parry
Jun 24, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bora GurelAngelo M De Marzo
Sep 12, 2008·The Journal of Biological Chemistry·Manisha TripathiVito Quaranta

❮ Previous
Next ❯

Citations

Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Johanna I PartanenJuha Klefström
Nov 24, 2011·Prostate Cancer·Kenneth C Valkenburg, Bart O Williams
Jun 24, 2011·Cancer Research·Hemal H MehtaKuk-Wha Lee
Jul 23, 2011·Genes & Cancer·Cheryl M KohAngelo M De Marzo
Mar 7, 2014·Hepatitis Monthly·Chunyan WangLi Cui
Sep 19, 2019·Cancer Metastasis Reviews·Carly E Martin, Karin List
Jan 24, 2014·Cancer Metastasis Reviews·Magdalena M GrabowskaRobert J Matusik
Apr 15, 2016·Biological Chemistry·Andrew S MurrayKarin List
Jun 2, 2015·Expert Opinion on Drug Discovery·Kenneth C Valkenburg, Kenneth J Pienta
Apr 16, 2020·International Journal of Molecular Sciences·Shoichiro MukaiToshiyuki Kamoto
Apr 18, 2018·Cold Spring Harbor Perspectives in Medicine·Juan M Arriaga, Cory Abate-Shen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.