HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Grazia ArpinoRichard M Elledge

Abstract

Preclinical data indicate that expression of the ErbB family of receptors, such as HER-2 and HER-1 (EGFR) may be involved in endocrine resistance. Evidence of resistance from clinical studies has been inconsistent. The present study examined whether HER-2 gene amplification or HER-1 expression predicted response to tamoxifen. Three hundred and forty nine patients had estrogen receptor (ER)-positive breast cancer and received daily tamoxifen as initial therapy for advanced disease. HER-2 gene amplification, detected by fluorescence in situ hybridization, and HER-1 expression, evaluated by immunohistochemistry, was determined on 136 and 204 patients, respectively. HER-2 amplification was correlated with lower ER (P = 0.02), HER-1 positivity (P = 0.004), and HER-2 protein overexpression (P < 0.00001). The response rate was 56% for HER-2 non-amplified versus 47% for HER-2 amplified tumors (P = 0.38), and 58% for HER-1-negative versus 36% for HER-1-positive (P = 0.05). Time to treatment failure (TTF) was 7 months for non-amplified HER-2 tumors and 5 months (P = 0.007) for amplified HER-2 tumors, and there was a trend toward a better overall survival (OS) in patients with non-amplified HER-2 tumors (median 31 versus 25 months, respec...Continue Reading

References

Aug 19, 1992·Journal of the National Cancer Institute·D R CioccaM R Pandian
Sep 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K LeitzelG Volas
Dec 1, 1990·Breast Cancer Research and Treatment·F SpyratosM Brunet
Oct 1, 1989·Breast Cancer Research and Treatment·M GrimauxH Magdelénat
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K LeitzelA Lipton
Oct 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C CarlomagnoS De Placido
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H YamauchiD F Hayes
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T W JacobsS J Schnitt
Jun 24, 2000·Molecular and Cellular Biology·J Font de Mora, M Brown
Oct 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D A BerryL Norton
Jan 17, 2003·Journal of the National Cancer Institute·Gottfried KonecnyDennis J Slamon
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard R LoveD Craig Allred
Mar 6, 2003·Journal of the National Cancer Institute·C Kent OsborneRachel Schiff

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Citations

Nov 8, 2005·Cancer Chemotherapy and Pharmacology·Junichi Kurebayashi
Feb 5, 2013·Cancer Chemotherapy and Pharmacology·Howard A Burris
Nov 23, 2006·Breast Cancer Research and Treatment·Matthew P GoetzJames N Ingle
Oct 23, 2008·Breast Cancer Research and Treatment·Gregory E WeitsmanLeigh C Murphy
Jul 31, 2012·Breast Cancer Research and Treatment·A J AgboolaI O Ellis
Sep 10, 2013·The Breast : Official Journal of the European Society of Mastology·Xiaoyong FuRachel Schiff
Jun 12, 2013·Cancer Letters·Chara A PittaAndreas I Constantinou
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane
Aug 25, 2009·Nature Reviews. Cancer·Elizabeth A Musgrove, Robert L Sutherland
Dec 15, 2010·Nature Reviews. Clinical Oncology·Javier CortésMaría Vidal
Jan 20, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A U Buzdar
Feb 18, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C H BarriosR Caponero
Oct 31, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J F R RobertsonL Petruzelka
Aug 3, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F MontemurroG Arpino
Jan 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·C Kent OsborneMark Sellers
Feb 25, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Todd W MillerCarlos L Arteaga
Aug 1, 2007·BMC Genomics·Katherine A HoadleyCharles M Perou
Jul 11, 2006·World Journal of Surgical Oncology·Amit AgrawalK L Cheung
Jun 5, 2008·Breast Cancer Research : BCR·Christina MagkouIoanna Giannopoulou
May 18, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy R PeckHallgeir Rui
Oct 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Todd W MillerCarlos L Arteaga
Mar 17, 2011·The Oncologist·Leonel F Hernandez-Aya, Ana M Gonzalez-Angulo
Jul 4, 2008·Pharmacogenomics·Patrick R Benusiglio
Jun 7, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Masakazu Toi, Yuichi Iino
Aug 25, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinichi WakamatsuKazuo Tamura
Mar 7, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hiroko YamashitaHirotaka Iwase
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wenle XiaNeil L Spector

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