HER-2 fluorescence in situ hybridization: results from the survey program of the College of American Pathologists.

Archives of Pathology & Laboratory Medicine
Diane L PersonsGail Habegger-Vance

Abstract

Fluorescence in situ hybridization (FISH) is a common method used to determine HER-2 status in breast cancer. Limited information is available concerning reproducibility of FISH in determining HER-2 gene amplification. To present proficiency testing results of FISH for HER-2 conducted by the Cytogenetics Resource Committee of the College of American Pathologists/American College of Medical Genetics. During the past 5 years, unstained sections from 9 invasive breast carcinomas were used for HER-2 FISH proficiency testing, allowing for comparison of FISH results among a large number of laboratories. Additional data were collected using an educational (ungraded) challenge and supplemental questions in the surveys. The number of laboratories participating in HER-2 FISH proficiency testing has increased steadily during the past 5 years (from 35 in 2000 to 139 in 2004). Reproducibility of test results among laboratories was excellent for breast tumors with low copy number (no HER-2 amplification) and for breast tumors with high copy number (HER-2 amplification). However, there was considerable variation in interpretation of results for a tumor with low-level HER-2 amplification that was tested on 2 separate occasions. Responses to su...Continue Reading

References

Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S ToikkanenH Joensuu
Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B A GustersonR Reed
Oct 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R SeshadriP Kitchen
Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J BaselgaL Norton
Aug 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M F PressK J Flom
Sep 25, 1998·Journal of the National Cancer Institute·A D ThorE T Liu
Feb 5, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R R Tubbs, M H Stoler
Oct 31, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G PaulettiD J Slamon
Dec 6, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·J CouturierX Sastre-Garau
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A LebeauU Löhrs
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D SeidmanC A Hudis
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R R TubbsT M Grogan
Jun 6, 2002·Journal of the National Cancer Institute·Patrick C RocheEdith A Perez
Jul 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael F PressLeslie Bernstein
Feb 27, 2003·Breast Cancer Research and Treatment·A D WattersJ M S Bartlett
Jul 24, 2003·The Journal of Molecular Diagnostics : JMD·Priti LalBeiyun Chen
Apr 29, 2004·JAMA : the Journal of the American Medical Association·Hadi YazijiAllen M Gown
May 20, 2004·Journal of the National Cancer Institute·Mark D PegramDennis J Slamon

❮ Previous
Next ❯

Citations

May 22, 2007·Breast Cancer Research : BCR·Coya TapiaLukas Bubendorf
Jan 1, 2007·Archives of Pathology & Laboratory Medicine·Antonio C WolffUNKNOWN American Society of Clinical Oncology/College of American Pathologists
Dec 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Dec 26, 2006·Expert Review of Molecular Diagnostics·Jennifer LaudadioDaynna J Wolff
May 10, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Di Leo
Jul 21, 2007·Human Pathology·Richard D PowellRaymond R Tubbs
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sandra RauserAxel Walch
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido SauterMichael F Press
Feb 14, 2009·Der Pathologe·J RüschoffO Stoss
Jun 18, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Joan AlbanellJosé Palacios
Sep 17, 2010·Updates in Surgery·Paolo ArnoneUmberto Veronesi
Jan 4, 2008·Histopathology·S J L PayneC A Wells
Jul 7, 2011·Clinical Breast Cancer·Helen SwedeCarolyn D Runowicz

❮ Previous
Next ❯

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