HER2 polymorphisms and breast cancer in Tunisian women

Genetic Testing and Molecular Biomarkers
I KallelAhmed Rebai

Abstract

HER2 has been thought to play a critical role in both breast cancer development and progression. Any functional polymorphisms can potentially affect breast cancer risk as well as cancer phenotype and outcome. In our study, we analyzed three polymorphisms in the HER2 gene: the single-nucleotide polymorphism (SNP) HER2 Ile(655)Val as well as another SNP (rs903506) close to it and a new screened dinucleotide repeat H(AC)I4 in intron 4, in a sample of 148 cases and 290 controls from the Tunisian population and investigated their association with breast cancer risk. For the HER2 Ile(655)Val, we found similar allele frequencies between cases and controls (frequency of I allele was 0.92 and 0.91, respectively). The same was observed for the noncoding SNP (rs903506). These two SNPs also showed no association with any clinical parameters, except the association of HER2 Ile(655)Val with tumor size (p = 0.002). But, a significant association was found between the short tandem repeat (STR) [H(AC)I4] and breast cancer risk at both genotypic and allelic levels (p = 0.0004 and p = 0.0001, respectively). Multivariate analysis with binary logistic regression of disease status on genotypes of the three polymorphisms confirmed the association of ...Continue Reading

References

Oct 11, 1991·Nucleic Acids Research·J PapewalisM F Rajewsky
Sep 1, 1988·Molecular and Cellular Biology·D F SternH Cao
Feb 1, 1997·Trends in Genetics : TIG·Y KashiM Soller
Mar 4, 2000·Journal of the National Cancer Institute·D XieW Zheng
Dec 7, 2000·Journal of the National Cancer Institute·M M AmeyawH L McLeod
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Dec 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sarel J FleishmanNir Ben-Tal
Jul 8, 2003·The Journal of Pathology·Caroline J WittonJohn M S Bartlett
Jul 9, 2003·Breast Cancer Research and Treatment·Robert MillikanLynn Dressler
Aug 2, 2003·Cancer Detection and Prevention·Abdelmajid KhabirRachid Jlidi
Aug 21, 2003·Journal of the National Cancer Institute·Michael HauptmannJeffery P Struewing
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Kazuya KuraokaWataru Yasui
May 6, 2004·Experimental and Molecular Pathology·Elif Akisik, Nejat Dalay
May 29, 2004·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·D PintoR Medeiros
Sep 18, 2004·Cancer Letters·Eskandar Kamali-SarvestaniAhmad Merat
Feb 8, 2005·Pathology International·Hee Jung AnKyung Sik Lee
Mar 4, 2005·Breast Cancer Research : BCR·Patrick R BenusiglioBruce Aj Ponder
Mar 9, 2005·Cancer Research·Hisayuki ShigematsuAdi F Gazdar
Jul 1, 2005·Breast Cancer Research : BCR·Stephanie E NelsonAmy Trentham-Dietz
Aug 23, 2005·Biochemical and Biophysical Research Communications·Daniela PintoRui Medeiros
Dec 27, 2005·Gene·Nicola NormannoDavid S Salomon
May 10, 2006·Cancer Genetics and Cytogenetics·Marjut PuputtiNina N Nupponen
Nov 23, 2006·British Journal of Cancer·P R BenusiglioB A J Ponder
Oct 24, 2008·Journal of Receptor and Signal Transduction Research·Najla KharratAhmed Rebaï

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Citations

Oct 18, 2014·Investigational New Drugs·Gerald S FalchookRazelle Kurzrock
Apr 20, 2010·Breast Cancer Research and Treatment·Su LuXishan Hao
Jan 17, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nicola CrestiAlan V Boddy
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Wei ChenYun-Lin Wei
Sep 29, 2018·Global Health, Epidemiology and Genomics·A AbbadF Radouani
Oct 23, 2012·Molecular Biology Reports·Oguz OzturkCihan Uras
Feb 20, 2021·Breast Cancer : Targets and Therapy·Adhitiya DaniyalRizky Abdulah

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Methods Mentioned

BETA
PCR
Genotyping
electrophoresis

Software Mentioned

GeneScan Analysis
Excel
Genetic Data Analyses
R

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