HER2/neu as a predictive factor in breast cancer

Clinical Breast Cancer
C Lohrisch, M Piccart

Abstract

One of the current trends in breast cancer research is to identify markers that can predict response to specific anticancer therapies; intense laboratory research and therapeutic trials are exploiting this strategy. The combination of cytotoxic drugs directed at the tumor population with the highest probability of being sensitive to them with molecules targeted at intracellular signaling and cell cycle control pathways, which may be deregulated as part of the malignant process, represents our best hope for improved survival in both early and advanced disease. The transmembrane tyrosine kinase receptor, HER2/neu, has been the subject of much investigation with respect to its prognostic value, predictive value, and as a target of antibody-mediated therapy. Retrospective evidence strongly suggests that HER2 overexpression is associated with decreased disease-free and overall survival in node-positive, and possibly also node-negative, breast cancer. Prospective trials have demonstrated that antibodies to HER2 can produce tumor responses in women with advanced disease that overexpresses this molecule. Moreover, the combination of such antibodies with cytotoxic drugs has been one of the few recent strategies to improve survival durat...Continue Reading

References

Jul 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B A GustersonR Reed
Apr 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D C AllredL Eudey
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K LeitzelA Lipton
Jan 1, 1997·Breast Cancer Research and Treatment·L M WittersA Lipton
Feb 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P C ClahsenM J van de Vijver
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·S RozanX Sastre-Garau
Jul 25, 1998·The Biochemical Journal·N J HellyerJ G Koland
Sep 25, 1998·Journal of the National Cancer Institute·A D ThorE T Liu
Sep 1, 1999·Genes, Chromosomes & Cancer·T A JärvinenJ Isola
Sep 11, 1999·Breast Cancer Research and Treatment·S MénardM I Colnaghi
Oct 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D A BerryL Norton
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S MénardG Bonadonna
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A D SeidmanC A Hudis
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H J BursteinE P Winer
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J PiccartJ M Nogaret

❮ Previous
Next ❯

Citations

Dec 17, 2008·Archives of Gynecology and Obstetrics·Mar MuñozJosé Schneider
Jul 4, 2003·The New England Journal of Medicine·Sjoerd RodenhuisUNKNOWN Netherlands Working Party on Autologous Transplantation in Solid Tumors
Jul 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Carrie R GraveelGeorge F Vande Woude
Aug 30, 2008·Schizophrenia Bulletin·Maria J Arranz, Shitij Kapur
Aug 18, 2006·Molecular and Cellular Biology·Rebecca S Muraoka-CookH Shelton Earp
Dec 19, 2009·Breast Cancer Research : BCR·Kristine M Frizzell, W Lee Kraus
Aug 24, 2012·PloS One·Keith R MillerEdward J Collins
Jul 1, 2012·Drug Discovery Today. Disease Mechanisms·Domenico IacopettaSuzanne Aw Fuqua
Dec 6, 2006·Cancer·Emad A RakhaIan O Ellis
Jan 8, 2013·Journal of Clinical Laboratory Analysis·Jonnathan G Santillán-BenítezAngel Ordóñez-Quiroz
Jul 23, 2011·International Journal of Cancer. Journal International Du Cancer·Terence C Chua, Neil D Merrett
Feb 24, 2006·Nature Reviews. Cancer·Jonathan M IrishGarry P Nolan
Mar 6, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Carmine FedeleClaudia De Lorenzo
Mar 18, 2017·International Journal of Molecular Sciences·Suneetha Amara, Venkataswarup Tiriveedhi
Jan 11, 2003·American Journal of Clinical Pathology·Jeffrey S Ross, Geoffrey S Ginsburg
Sep 1, 2019·Cancers·Margherita PassarielloClaudia De Lorenzo
Jun 3, 2005·Carcinogenesis·Claudia De LorenzoGiuseppe D'Alessio
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kimberly L BlackwellLyndsay N Harris
Nov 5, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander MuckenhuberWilko Weichert
Jul 17, 2004·Cancer Research·Claudia De LorenzoGiuseppe D'Alessio
Apr 12, 2003·Surgical Oncology·Rolf J CravenWilliam G Cance

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.