HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1

Thoracic Cancer
Toru KumagaiFumio Imamura

Abstract

Activating EGFR mutations, HER2, and HER3 are implicated in lung cancer; however, with the exception of EGFR gene amplification in lung adenocarcinoma harboring EGFR mutations, their involvement in disease progression during the early stages is poorly understood. In this paper, we focused on which receptor is correlated with lung adenocarcinoma progression in the presence or absence of EGFR mutation from stage 0 to IA1. HER2 and HER3 expression and activating EGFR mutations in surgically resected lung adenocarcinoma exhibiting ground glass nodules on chest computed tomography and re-classified to stage 0 and IA1 were examined by immunohistochemistry and peptide nucleic acid-locked nucleic acid PCR clamp method, respectively. HER2 and HER3 expression was detected in 22.2% and 86.1% of samples, respectively. The frequency of EGFR mutation was 45.7% and was not significantly different between stage 0 and IA1 (40.0% and 48.0%, respectively), suggesting that EGFR mutation does not correlate with cancer progression from stage 0 to IA1. HER2 expression also did not correlate to progression. However, not only the frequency, but also the intensity of HER3 expression was increased in stage IA1 lung adenocarcinoma, particularly in lung ad...Continue Reading

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Citations

Oct 26, 2018·Investigational New Drugs·Wei WangHao Gong
Dec 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xia ZouYan Zhang
Oct 31, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Zhen HuangJian-Hua Lin
Jun 5, 2021·Lung Cancer Management·Thubeena ManickavasagarAnna Minchom
Aug 7, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Barbara MeloskyQuincy Chu

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Methods Mentioned

BETA
bronchoalveolar
PCR
light microscopy
surgical resection

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