Her4-positive population in the tectum opticum is proliferating neural precursors in the adult zebrafish brain.

Molecules and Cells
Seung-Hyun JungSang-Yeob Yeo

Abstract

Previous studies have shown that Notch signaling not only regulates the number of early differentiating neurons, but also maintains proliferating neural precursors in the neural tube. Although it is well known that Notch signaling is closely related to the differentiation of adult neural stem cells, none of transgenic zebrafish provides a tool to figure out the relationship between Notch signaling and the differentiation of neural precursors. The goal of this study was to characterize Her4-positive cells by comparing the expression of a fluorescent Her4 reporter in Tg[her4-dRFP] animals with a GFAP reporter in Tg[gfap-GFP] adult zebrafish. BrdU incorporation indicated that dRFP-positive cells were proliferating and a double labeling assay revealed that a significant fraction of the Her4-dRFP positive population was also GFAP-GFP positive. Our observations suggest that a reporter line with Notch-dependent gene expression can provide a tool to examine proliferating neural precursors and/or neuronal/glial precursors in the development of the adult nervous system to examine the model in which Notch signaling maintains proliferating neural precursors in the neural tube.

References

Nov 4, 2000·Neurochemical Research·L F EngY L Lee
Jul 24, 2004·Trends in Neurosciences·Gerd KempermannGolo Kronenberg
Sep 8, 2005·Current Opinion in Neurobiology·Dengke K MaHongjun Song
Jun 13, 2006·Gene Expression Patterns : GEP·Rebecca L Bernardos, Pamela A Raymond
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sang-Yeob Yeo, Ajay B Chitnis
May 4, 2007·Current Opinion in Neurobiology·Jovica Ninkovic, Magdalena Götz
Dec 17, 2008·Biochemical and Biophysical Research Communications·Ju-Hoon SoSang-Yeob Yeo
Jan 24, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chen Sok LamUwe Strähle
Mar 31, 2011·Molecules and Cells·Thi-Minh-Tho DamCheol-Hee Kim

❮ Previous
Next ❯

Citations

Jul 16, 2013·Molecules and Cells·Yong-Il KimCheol-Hee Kim
Dec 1, 2015·Experimental Eye Research·Stephen G WilsonAnn C Morris
Apr 1, 2017·Molecules and Cells·Kyeong-Won YooCheol-Hee Kim
Dec 5, 2019·Thyroid : Official Journal of the American Thyroid Association·Inbal AdmatiLior Appelbaum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.