Abstract
Herb-induced liver injury (HILI) has recently attracted attention due to increasing reports of hepatotoxicity associated with use of phytotherapeutics. Here, we present data on HILI from the Berlin Case-Control Surveillance Study. The study was initiated in 2000 to investigate the serious toxicity of drugs including herbal medicines. Potential cases of liver injury were ascertained in more than 180 Departments of all 51 Berlin hospitals from October 2002 to December 2011. Drug or herb intake was assessed through a standardized face-to-face interview. Drug or herbal aetiology was assessed based on the updated Council for International Organizations of Medical Sciences scale. In ten of all 198 cases of hepatotoxicity included in the study, herbal aetiology was assessed as probable (once ayurvedic herb) or possible (Valeriana five times, Mentha piperita once, Pelargonium sidoides once, Hypericum perforatum once, Eucalyptus globulus once). Mean age was 56.4 ± 9.7 years, and the predominant pattern of liver injury was hepatocellular. No cases of acute liver failure or death were observed. This case series corroborates known risks for ayurvedic herbs, supports the suspected association between Valeriana use and liver injury, and indi...Continue Reading
References
Dec 28, 1979·JAMA : the Journal of the American Medical Association·J B SullivanP Bryson
Sep 1, 1990·Journal of Hepatology·C Bénichou
Nov 4, 1989·BMJ : British Medical Journal·F B MacGregorP C Hayes
Apr 15, 1996·Annals of Internal Medicine·I B AndersonP D Blanc
Oct 22, 1955·Lancet·W B VALLANCE
Oct 1, 2003·Clinical and Experimental Pharmacology & Physiology·Liem T VoRoger G King
Sep 11, 2004·Archives of Pharmacal Research·Nam Hee KimTae Cheon Jeong
Apr 2, 2005·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·O A Jorge, A D Jorge
Oct 4, 2006·Alimentary Pharmacology & Therapeutics·M-F YuenC-L Lai
Apr 24, 2008·Journal of Clinical Gastroenterology·Daniel L Cohen, Yanisa Del Toro
Jan 14, 2009·Sleep Medicine·Themistoklis VassiliadisNikolaos Eugenidis
Oct 15, 2009·Seminars in Liver Disease·Victor J Navarro
Feb 22, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Sri DantuluriSivaramakrishnan V Karthik
Jan 1, 2009·BMJ Case Reports·Paola PiccoloMario Angelico
Jul 14, 2011·British Journal of Haematology·Edeltraut GarbeHanife Kurtal
Aug 23, 2011·Gastroenterology·Timothy J DavernUNKNOWN Drug-Induced Liver Injury Network (DILIN)
Oct 28, 2011·Clinical Therapeutics·Chung-Hsuen WuJae Kennedy
Mar 3, 2012·Regulatory Toxicology and Pharmacology : RTP·Rolf TeschkeAxel Eickhoff
Jun 26, 2012·Regulatory Toxicology and Pharmacology : RTP·Thomas Stammschulte, Ursula Gundert-Remy
Aug 30, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Rolf TeschkeAxel Eickhoff
Aug 21, 2013·Alimentary Pharmacology & Therapeutics·A DourosE Garbe
Mar 22, 2014·World Journal of Hepatology·Rolf TeschkeAxel Eickhoff
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Victor J NavarroRaj Vuppalanchi
Dec 3, 2014·British Journal of Clinical Pharmacology·Antonios DourosEdeltraut Garbe
Feb 15, 2015·Archives of Toxicology·Felix Stickel, Daniel Shouval
Jul 8, 2015·Expert Opinion on Drug Metabolism & Toxicology·Carlemi CalitzSias Hamman
Oct 16, 2015·The New England Journal of Medicine·Andrew I GellerDaniel S Budnitz
Citations
Sep 9, 2016·International Journal of Molecular Sciences·Rolf Teschke, Raúl J Andrade
Nov 9, 2016·Expert Opinion on Drug Metabolism & Toxicology·Rolf Teschke, Gaby Danan
Jul 19, 2016·Medicines·Rolf TeschkeGaby Danan
Mar 11, 2018·BMJ Case Reports·David Noiva PerdigotoLuis Tomé
Aug 5, 2017·Expert Opinion on Drug Metabolism & Toxicology·Omar ShahbazJames H Lewis
May 6, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yixuan LiChunze Zhang
Aug 29, 2020·Toxicology Mechanisms and Methods·Andreas F LehnerDaniel K Langlois
Jul 24, 2018·Therapeutic Advances in Gastroenterology·Michael H K ChuVincent C H Chung
Oct 23, 2018·Integrative Cancer Therapies·Ge GuoMitzi Nagarkatti
Mar 6, 2019·BioMed Research International·Binh-Hai TranRalph Mösges
Oct 3, 2020·Medicines·Rolf Teschke, Gaby Danan
Oct 10, 2020·World Journal of Hepatology·Cyriac Abby PhilipsPhilip Augustine
Jan 13, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Fernando BessoneRaúl J Andrade
Feb 14, 2021·The Journal of Emergency Medicine·Gavin KoenigJanet A Smereck
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Majid TafrihiRaffaele Pezzani
Sep 24, 2021·Annals of Hepatology·Pedro Felipe SoaresRaymundo Paraná