Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study

International Journal of Molecular Sciences
A DourosJuliane Bolbrinker

Abstract

Herb-induced liver injury (HILI) has recently attracted attention due to increasing reports of hepatotoxicity associated with use of phytotherapeutics. Here, we present data on HILI from the Berlin Case-Control Surveillance Study. The study was initiated in 2000 to investigate the serious toxicity of drugs including herbal medicines. Potential cases of liver injury were ascertained in more than 180 Departments of all 51 Berlin hospitals from October 2002 to December 2011. Drug or herb intake was assessed through a standardized face-to-face interview. Drug or herbal aetiology was assessed based on the updated Council for International Organizations of Medical Sciences scale. In ten of all 198 cases of hepatotoxicity included in the study, herbal aetiology was assessed as probable (once ayurvedic herb) or possible (Valeriana five times, Mentha piperita once, Pelargonium sidoides once, Hypericum perforatum once, Eucalyptus globulus once). Mean age was 56.4 ± 9.7 years, and the predominant pattern of liver injury was hepatocellular. No cases of acute liver failure or death were observed. This case series corroborates known risks for ayurvedic herbs, supports the suspected association between Valeriana use and liver injury, and indi...Continue Reading

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Citations

Sep 9, 2016·International Journal of Molecular Sciences·Rolf Teschke, Raúl J Andrade
Nov 9, 2016·Expert Opinion on Drug Metabolism & Toxicology·Rolf Teschke, Gaby Danan
Mar 11, 2018·BMJ Case Reports·David Noiva PerdigotoLuis Tomé
May 6, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yixuan LiChunze Zhang
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Jul 24, 2018·Therapeutic Advances in Gastroenterology·Michael H K ChuVincent C H Chung
Oct 10, 2020·World Journal of Hepatology·Cyriac Abby PhilipsPhilip Augustine
Jan 13, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Fernando BessoneRaúl J Andrade
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Sep 24, 2021·Annals of Hepatology·Pedro Felipe SoaresRaymundo Paraná

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Methods Mentioned

BETA
biopsy

Software Mentioned

DILIN
FAKOS

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