Herb-Partitioned Moxibustion Regulates the TLR2/NF-κB Signaling Pathway in a Rat Model of Ulcerative Colitis

Evidence-based Complementary and Alternative Medicine : ECAM
Xiaomei WangHuan-Gan Wu

Abstract

The TLR2/NF-κB signaling pathway plays an important role in the pathomechanism of ulcerative colitis (UC); acupuncture and moxibustion can improve the damage in colonic tissues of UC, but the regulatory mechanism remains unknown. This study observed the effect of moxibustion on the TLR2/NF-κB signaling pathway at the Tianshu (ST25) and Qihai (CV6) acupuncture points in the UC rat. The result shows that TLR2, IRAK1, and IKK-b mRNA and protein levels in the colonic mucosa were significantly higher in the UC rats than in the control rats. Herb-partitioned moxibustion reduced the expression of TLR2, IRAK1, and IKK-b mRNA and proteins in the UC rats. Similarly, the expression of NF-κB was significantly increased and IFN-β and IL-10 were significantly decreased in the colonic mucosa of UC rats, but herb-partitioned moxibustion reduced the expression of IFN-β and upregulating the expression of IFN-β and IL-10 significantly. It indicates that herb-partitioned moxibustion can inhibit the expression of multiple signaling molecules of the TLR2 pathway effectively, and it may modulate the excessive local immune response by inhibiting TLR2 signaling, thereby promoting the repair of damaged colonic mucosa.

References

Jun 3, 2000·Nature Genetics·N C ArbourD A Schwartz
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Randy JacintoLiwu Li
Nov 24, 2004·American Journal of Respiratory Cell and Molecular Biology·Arata AzumaShoji Kudoh
Dec 21, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shinichiro WatanabeOsamu Kimura
May 18, 2007·Clinical Pharmacology and Therapeutics·F SchinzariC Cardillo
May 29, 2009·Pharmacological Reviews·Luke A J O'NeillSarah L Doyle
Nov 13, 2010·European Journal of Clinical Investigation·Johannes J KovarikGerhard J Zlabinger
Dec 5, 2012·Journal of Clinical Immunology·Gabriela Fonseca-CamarilloJesús K Yamamoto-Furusho
Jul 10, 2014·Current Topics in Microbiology and Immunology·Karin R Engelhardt, Bodo Grimbacher

❮ Previous
Next ❯

Citations

Aug 21, 2018·World Journal of Gastroenterology : WJG·Dan ZhangXiao-Peng Ma
Jul 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Daneng WeiQiaofeng Wu
Apr 4, 2021·International Immunopharmacology·Atieh YaghoubiSaman Soleimanpour
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mohamed A MorsyYasmine F Ibrahim

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

MOTIC
primer
PASS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.