Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats

Drug Development Research
Xiujie LiuRongji Dai

Abstract

Preclinical Research Baogan Yihao (BGYH) is a traditional Chinese herbal medicine for the treatment of chronic liver diseases. In this study, the effects of BGYH on dimethylnitrosamine (DMN)-induced liver fibrosis were investigated using a rat model. BGYH alleviate liver damage, as indicated by decreased levels of AST, ALT, γ-GT, and AKP. BGYH also prevented collagen deposition and reduced pathological tissue injury in liver tissue. In fibrosis, high levels of α-SMA and TGF-β in liver tissue were markedly attenuated by BGYH. The inhibitory effect of BGYH on HSC-T6 proliferation demonstrated that BGYH exhibited significant hepatoprotective and antifibrogenic effects on DMN-induced liver injury. These findings suggest that BGYH may have therapeutic potential in the prevention and therapy of liver fibrosis. Drug Dev Res 78 : 155-163, 2017. © 2017 Wiley Periodicals, Inc.

References

Nov 1, 1991·Journal of Hepatology·P J Scheuer
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elke UeberhamRolf Gebhardt
Jul 11, 2013·World Journal of Gastroenterology : WJG·Dong-Hui WangXue-Ling Cui
Aug 29, 2013·World Journal of Gastroenterology : WJG·Feng-Rui YangJian-Shi Lou
Apr 29, 2015·Journal of Hepatology·Christian TrautweinMassimo Pinzani
Jun 25, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammed Riaz Hasan ChowdhuryMd Ashraful Alam
Aug 2, 2015·Journal of Hepatology·Frank Tacke, Christian Trautwein
Mar 17, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tae-Won KimJoo-Won Suh
May 31, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Ning WangYibin Feng
Jun 14, 2016·Canadian Journal of Physiology and Pharmacology·Ying-Hua HeJun Li
Sep 2, 2016·Biological & Pharmaceutical Bulletin·Hiroki YoshiokaAkito Nagatsu

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