Herbal formulation, Yukmi-jihang-tang-Jahage, regulates bone resorption by inhibition of phosphorylation mediated by tyrosine kinase Src and cyclooxygenase expression

Journal of Ethnopharmacology
Un-Ho JinCheorl-Ho Kim

Abstract

Anti-bone resorption properties of the Korean herbal medicine, Yukmi-jihang-tang (YJ), which is comprised of seven herbs such as Rehmannia glutinosa Libosch, Dioscorea japonica THUNB, Cornus officinalis SIEB et. ZUCC, Smilax glabra ROXB, Paeonia suffruticosa ANDR, Alisma platago-aquatica var. orientale SAMUELS and Hominis placenta, were investigated. Cyclooxygenase-2 (COX-2) and tyrosine kinase involve on prostaglandin E2 (PGE2) production in mouse calvarial osteoblasts stimulated by cytokine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6). IL-1beta and IL-6 and to a lesser extent TNF-alpha, enhanced COX-2 mRNA levels in calvarial osteoblasts. TGF-beta, YJ (100microg/ml) and their combinations of YJ+TGF-beta reduced the COX-2 mRNA level, PGE2 biosynthesis and bone resorption induced by IL-1beta, TNF-alpha, IL-6 or their combination. Finally, YJ inhibits in vitro and in vivo bone resorption by inhibition of phosphorylation of peptide substrates. The parathyroid hormone-induced bone resorption in mouse fetal long bone cultures was inhibited with an IC(50) of 16microg/ml. YJ dose-dependently reduced the hypercalcemia induced in mice by IL-1beta and partly prevented bone loss and mi...Continue Reading

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Citations

Oct 14, 2008·Genes & Nutrition·Yu Na YounSoon Young Choi
Apr 6, 2012·Southern Medical Journal·Sarah FrenchStephen Geraci
Feb 9, 2012·Bioscience, Biotechnology, and Biochemistry·Masatoshi YamaguchiKazuhiko Arimori
Dec 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Byoung-Seob KoSunmin Park
May 21, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong Wook Lim, Yun Tai Kim
Apr 15, 2008·Journal of Ethnopharmacology·Ru-Xue ZhangZheng-Ping Jia
Mar 1, 2011·Toxicological Research·Hye-Jeong KimYoung-Chul Kim
Sep 1, 2011·Toxicological Research·Pham Thi Thu Huong, Young Jin Jeon
Feb 13, 2018·The American Journal of Chinese Medicine·Shiyao HuaXueyan Fu
Jun 11, 2011·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Pham Thi Thu HuongYoung Jin Jeon
Dec 28, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Pham Thi Thu HuongYoung Jin Jeon
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May 4, 2017·BMC Complementary and Alternative Medicine·Sung-Min ChoJin Yong Lee

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