Herbal treatment with uva ursi extract versus fosfomycin in women with uncomplicated urinary tract infection in primary care: a randomized controlled trial.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Ildikó GágyorJutta Bleidorn

Abstract

We explored whether initial treatment with the herbal drug uva ursi (UU) reduces antibiotic use in women with uncomplicated urinary tract infection (UTI) without increasing symptom burden and complication frequency compared with antibiotic treatment. A double-blind randomized controlled trial was conducted in 42 family practices in Germany. The participants were adult women with suspected uncomplicated UTIs receiving either UU 105 mg 3 × 2 tablets for 5 days (intervention) or fosfomycin a 3-g single dose (control), and their respective placebos. Participants and investigators were blinded. The primary outcome included (1) antibiotic courses day 0-28 as superiority, and (2) symptom burden (sum of daily symptom scores) day 0-7, as non-inferiority outcome (margin 125%). Clinicaltrials.gov: NCT03151603. Overall, 398 patients were randomly allocated to groups receiving UU (n = 207) and fosfomycin (n = 191). The number of antibiotic courses was 63.6% lower (95% CI 53.6%-71.4%; p < 0.0001) in the UU group than in the fosfomycin group. The ratio of total symptom burden in the UU group compared with control was 136.5% (95% CI 122.7-151.9; p 0.95), failing non-inferiority. Eight women developed pyelonephritis in the UU group compared wit...Continue Reading

References

Feb 9, 2010·BMJ : British Medical Journal·G M LeydonUNKNOWN UTIS team
Feb 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kalpana GuptaUNKNOWN European Society for Microbiology and Infectious Diseases
May 10, 2015·BMJ : British Medical Journal·Kirsty LoudonMerrick Zwarenstein
Sep 29, 2015·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Chris C ButlerCliodna Am McNulty
Dec 25, 2015·BMJ : British Medical Journal·Ildikó GágyorEva Hummers-Pradier
Jan 28, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M MooreG Griffiths
May 9, 2019·Journal of Tropical Medicine·Sarita ManandharRaj Kumar Dahal

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Citations

Jul 17, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Lindsay Nicolle
Sep 21, 2021·The Journal of Antimicrobial Chemotherapy·Ildikó Gágyor, Alastair D Hay
Nov 7, 2021·BJU International·Mary ZareFlorian Wagenlehner

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