Hereditary breast cancer: an update on risk assessment and genetic testing in 2015

American Journal of Obstetrics and Gynecology
Ashley R Stuckey, Michaela A Onstad

Abstract

The last 5 years have brought significant innovation and advancement in the genetics of breast cancer. This clinical opinion aims to summarize and update current approaches to the care of women at risk for a hereditary predisposition to breast cancer. Implications of the BRCA mutation and several other hereditary syndromes will be discussed. Risk assessment and criteria for referral to cancer genetic professionals as well as high-risk screening and prophylactic options will be reviewed. Finally, the newly available genetic cancer panels and implications of mutations in some of these lesser known genes will be discussed. As the field of cancer genetics continues to evolve, the education of medical students, residents, and faculty will be paramount to identify appropriate candidates for genetic counseling and testing in conjunction with cancer genetic professionals.

References

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Citations

Sep 8, 2015·Vaccines·Pier-Luigi LolliniElena Quaglino
Nov 13, 2016·The Breast : Official Journal of the European Society of Mastology·Anne BrédartSylvie Dolbeault
Feb 7, 2017·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Michiko T YasudaKayoko Shimoi
Oct 3, 2017·Personalized Medicine·Sarah A WalserBarbara A Bernhardt
Jul 13, 2018·Human Genomics·Isabelle CusinPascale Gaudet

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