PMID: 8939282Jan 1, 1996Paper

Hereditary cerebral hemorrhage with amyloidosis-Dutch type: better correlation of cognitive deterioration with advancing age than with number of focal lesions or white matter hyperintensities

Alzheimer Disease and Associated Disorders
M BornebroekR A Roos

Abstract

The relationship between cognitive deterioration and abnormalities detected by magnetic resonance imaging (MRI) was investigated to determine the radiological correlates of cognitive deterioration in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). Twenty HCHWA-D subjects (12 patients who had suffered one or more strokes and eight who had not suffered a stroke) were studied with MRI and underwent extensive neuropsychological examination. On MRI the number of focal lesions was counted, and white matter hyperintensities (WMHs) were scored semiquantitatively. A significant correlation between cognitive deterioration and WMH score and number of focal lesions was found. However, cognitive deterioration, WMH score, and the number of focal lesions all increase with age, and therefore their mutual correlation can be explained as an age effect. This study shows that cognitive deterioration in HCHWA-D is not correlated with abnormalities detected by MRI (number of focal lesions and subcortical WMHs) independently of age. Although a contribution of white matter changes and/or focal lesions, possibly in combination with age, to cognitive deterioration cannot be excluded. Cognitive deterioration in these HCHWA-D patient...Continue Reading

Citations

Dec 18, 2003·Neurobiology of Disease·Marjolijn BornebroekChristine Van Broeckhoven
Dec 31, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Marion Maat-SchiemanSjoerd van Duinen
Nov 1, 2015·Biochimica Et Biophysica Acta·William E Van Nostrand
Oct 11, 2005·Journal of the Neurological Sciences·Peter K PanegyresPeter C Blumbergs
Aug 16, 2005·Brain and Cognition·John T E Richardson
Jul 17, 1998·Neurologic Clinics·J Y ChoiC Y Hsu
Dec 18, 2009·Neurobiology of Aging·Kim S RutgersSilvère M van der Maarel
May 13, 2006·Cerebrovascular Diseases·Luís F MaiaManuel Correia
Jun 27, 2009·Stroke; a Journal of Cerebral Circulation·Sanneke van RoodenMark A van Buchem
Nov 12, 2016·Stroke; a Journal of Cerebral Circulation·Sanneke van RoodenMark A van Buchem
Jan 30, 2007·The Journal of Biological Chemistry·Michael D HoosWilliam E Van Nostrand
Jun 12, 1998·The New England Journal of Medicine·J A Fishman, R H Rubin
Mar 17, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·P Sampathkumar, C V Paya
Sep 10, 2008·Expert Opinion on Pharmacotherapy·Hsin-Yun Sun, Nina Singh
Jul 21, 2009·Journal of Cutaneous Pathology·Brian L SwickMary Seabury Stone
Jun 30, 2015·The Pediatric Infectious Disease Journal·Kensuke ShojiAkihiko Saitoh
Oct 19, 1999·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·M BornebroekR A Roos
Apr 15, 2006·Brain Pathology·Sandy X Zhang-NunesSteven M Greenberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.