Hereditary Colorectal Cancer: Genetics and Screening

The Surgical Clinics of North America
Lodewijk A A BrosensFrancis M Giardiello

Abstract

Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.

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Citations

Feb 7, 2017·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Michiko T YasudaKayoko Shimoi
Jan 2, 2016·International Journal of Surgical Pathology·Lodewijk A A BrosensElizabeth A Montgomery
Oct 30, 2019·Hereditary Cancer in Clinical Practice·Muhammad Usman RashidMuhammed Aasim Yusuf
Dec 5, 2019·World Journal of Clinical Cases·Hussein SabitHuseyin Tombuloglu
Jun 19, 2019·United European Gastroenterology Journal·Amelie S TroschelIyad Kabar
Aug 11, 2020·Surgical Pathology Clinics·Shoko VosLodewijk A A Brosens
Jun 23, 2021·International Journal of Colorectal Disease·Ryo KatsumataKen Haruma
Jul 3, 2021·International Journal of Molecular Sciences·Miljana NenkovYuan Chen
Aug 28, 2021·International Journal of Environmental Research and Public Health·Abdul Rahman RamdzanSyed Mohamed Aljunid

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