Hereditary fructose intolerance and celiac disease: a novel genetic association

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Carolina CiacciLucia Sacchetti

Abstract

Celiac disease (CD) has been associated with several genetic disorders, but has not been associated with hereditary fructose intolerance (HFI). We identified CD in 4 female patients affected by HFI from among 38 Italian HFI patients. Three of these patients were children in whom the CD-associated signs were hypertransaminasemia, failure to thrive, low weight, and short stature, whereas the adult patient had protracted diarrhea notwithstanding a fructose-free diet. The incidence of CD in our group of HFI patients was higher (>10%) than in the general population (1%-3%) (P<.02). The possibility of an association between these 2 gastrointestinal disorders is important, particularly in the management of HFI patients with persisting symptoms.

References

Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M T BardellaR De Franchis
Dec 31, 2004·Journal of Pediatric Gastroenterology and Nutrition·Ivor D HillUNKNOWN North American Society for Pediatric Gastroenterology, Hepatology and Nutrition

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Citations

Mar 31, 2012·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Lalit Bharadia, Deepak Shivpuri
Jun 3, 2011·World Journal of Gastroenterology : WJG·Hugh James FreemanAlan Br Thomson
Dec 30, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Francesca MarcianoPietro Vajro
Apr 14, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·V NobiliU Raucci
Aug 19, 2014·International Journal of Hepatology·Manuela ScorzaGiuseppe Castaldo
Sep 16, 2021·Human Mutation·Franciele C PinheiroIda V D Schwartz

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