PMID: 6973947Jan 1, 1981Paper

Hereditary hemorrhagic telangiectasia and disseminated intravascular coagulation: a new clinical syndrome

Annals of the New York Academy of Sciences
R L Bick

Abstract

In summary, 47 patients with documented HHT and a bleeding problem were referred to San Joaquin Hematology Oncology Medical Group over a 2-year period. Fifty-one percent of patients were noted to have an associated DIC syndrome and of these 24 patients, 19 had acute DIC episodes, six had chronic DIC, six presented with diffuse, recurrent deep venous thrombosis and of these six, three suffered pulmonary emboli. Other defects were also noted and were thought to be coincidental defects. This syndrome should be readily considered and searched for when seeing patients with HHT, especially if significant hemorrhage or thrombosis is present. It should further be appreciated that many patients with HHT and bleeding are candidates for the development of acute or chronic DIC and thus a "mini" Kasabach-Merritt syndrome. When patients with HHT present with undue bleeding, this syndrome should be appreciated, searched for from the clinical and laboratory standpoint and, when found, treated in the appropriate manner with supportive therapy, mini-heparin or antiplatelet therapy as the clinical situation dictates.

References

Mar 1, 1976·Thrombosis Research·R L BickN R Arbegast
Jan 1, 1979·Seminars in Thrombosis and Hemostasis·R L Bick

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Citations

Nov 3, 1994·The New England Journal of Medicine·J R KorzenikR White
Nov 10, 2013·Journal of Thrombosis and Thrombolysis·Christophe VandenbrieleKathelijne Peerlinck
Apr 1, 1986·The British Journal of Radiology·I J Kenney, I G Mackay
Feb 7, 2009·International Journal of Obstetric Anesthesia·H El ShobaryI Kaufman
Jul 22, 2014·Journal of Thrombosis and Haemostasis : JTH·S GaillardUNKNOWN ATERO Study Group
May 7, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rodger L Bick
Sep 25, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Atsushi YasumotoYutaka Yatomi
Sep 10, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Wolfgang SturmGünter Weiss
Oct 21, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Laurent ArdillonCedric Hermans
Jul 10, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·R Bick
Dec 8, 2020·Phlebology·Eleanor J BudgeChung Sim Lim

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