Hereditary hemorrhagic telangiectasia-related epistaxis: innovations in understanding and management

International Forum of Allergy & Rhinology
Nathan B Sautter, Timothy L Smith

Abstract

Epistaxis is the most common manifestation of hereditary hemorrhagic telangiectasia (HHT), affecting approximately 90% of patients at some point during their lifetime. Bleeding is chronic and varies from mild, self-limited episodes to severe, transfusion-dependent or life-threatening epistaxis. Treatment options vary from conservative, nonsurgical management to more aggressive surgical approaches. A number of treatment options have been introduced in recent years. There is little consensus in the literature regarding treatment algorithms. The objective of this investigation was to provide a contemporary review of HHT-related epistaxis, including pathophysiology, disease manifestations, and state-of-the-art treatment modalities. A systematic review of the literature for HHT-related epistaxis was performed using the search terms "hereditary hemorrhagic telangiectasia" and "epistaxis." Additional literature search regarding current recommendations for HHT evaluation and recent developments in genetic mechanisms, pathophysiology, and treatment of HHT was also performed. A total of 308 articles were identified and reviewed for appropriateness of inclusion whereas 64 articles met inclusion criteria. Treatment options range from topic...Continue Reading

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Citations

Feb 14, 2013·The Laryngoscope·B Maneesha SilvaClaire L Shovlin
Feb 2, 2012·The Laryngoscope·Nathan B SautterDennis R Trune
Oct 16, 2012·International Forum of Allergy & Rhinology·David W Kennedy
Mar 19, 2014·The Laryngoscope·Matthew R PurkeyRakesh Chandra
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Aug 16, 2016·Clinics in Chest Medicine·Joseph G Parambil
Jan 29, 2014·The Journal of Craniofacial Surgery·Joo Yeon KimJae Hwan Kwon
Oct 1, 2019·The Laryngoscope·Nadim KhoueirBenjamin Verillaud
Jun 22, 2017·Ear, Nose, & Throat Journal·Christopher F ThompsonMarilene B Wang
Nov 4, 2020·BMJ Case Reports·Eve Mandisa Rader Bowers, Stella Lee
Apr 19, 2021·Orphanet Journal of Rare Diseases·F HaubnerF Kashani

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