Hereditary iron overload

Pathologie-biologie
Pierre BrissotA-M Jouanolle

Abstract

The field of hereditary iron overload has known, in the recent period, deep changes mainly related to major advances in molecular biology. It encompasses now a series of genetic entities. The mechanistic understanding of iron overload development and iron toxicity has greatly improved. The diagnostic approach has become essentially noninvasive with a major role for biological tests. From the therapeutic viewpoint, the phlebotomy treatment is now enriched by the possibility of resorting to oral chelation and by innovative perspectives directly linked to our improvement in the molecular understanding of these diseases.

References

Oct 1, 1978·British Journal of Haematology·C HershkoE A Rachmilewitz
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C M CravenJ Kaplan
Oct 27, 1999·Gastroenterology·M H MendlerY Deugnier
May 10, 2000·Nature Genetics·C CamaschellaP Gasparini
Mar 12, 2002·European Journal of Clinical Investigation·Robert C Hider
Aug 14, 2003·Human Molecular Genetics·Alison T Merryweather-ClarkeKathryn J H Robson
Dec 3, 2003·Nature Genetics·George PapanikolaouY Paul Goldberg
Jan 27, 2005·Blood·Caroline Le LanPierre Brissot
Mar 2, 2005·Best Practice & Research. Clinical Haematology·Z Ioav CabantchikP Cianciulli
Jun 25, 2005·Current Protein & Peptide Science·Olivier LoréalPierre Brissot
Apr 11, 2006·Nature Genetics·Jodie L BabittHerbert Y Lin
Jan 18, 2008·The New England Journal of Medicine·Katrina J AllenDorota M Gertig
Mar 5, 2008·Cell Metabolism·Paul J SchmidtNancy C Andrews
Apr 24, 2008·Blood Reviews·Pierre BrissotOlivier Loréal
Jul 9, 2008·Blood·Nancy C Andrews
Aug 12, 2008·Blood·Tomas GanzMark Westerman
Sep 23, 2008·Journal of Hepatology·Dorine W Swinkels, Joost P H Drenth
Mar 3, 2009·Nature Genetics·Billy AndriopoulosJodie L Babitt
Mar 3, 2009·Nature Genetics·Delphine MeynardMarie-Paule Roth
Apr 4, 2009·Current Opinion in Gastroenterology·Antonello Pietrangelo
Apr 23, 2009·Blood·Augustine FernandesElizabeta Nemeth
Jun 19, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Hélène DuvalGérard Chales
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lyle C GurrinUNKNOWN HealthIron Study Investigators
Jun 27, 2009·Biochimie·Lydie Viatte, Sophie Vaulont

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.