Hereditary medullary thyroid cancer: age-appropriate thyroidectomy improves disease-free survival

Annals of Surgical Oncology
Kevin ShepetHerbert Chen

Abstract

Twenty-five percent of medullary thyroid cancer (MTC) cases are hereditary. The ideal age for prophylactic thyroidectomy is based on the specific RET mutation involved. The purpose of this study was to determine whether such age-appropriate prophylactic thyroidectomy results in improved disease-free survival. Twenty-eight patients underwent thyroidectomy for hereditary MTC at our institution. Age-appropriate thyroidectomy was defined according to the North American Neuroendocrine Tumor Society (NANETS) guidelines. Patients who had age-appropriate surgery (group 1, n = 9) were compared to those who had thyroidectomy past the recommended age (group 2, n = 19). The mean age was 13 ± 2 years, and 61 % were female. Patients in group 1 were younger than in group 2 (4 ± 1 vs. 17 ± 2 years, p < 0.01). There were no significant differences in gender or RET mutation types between these two groups. Group 1 patients were cured with no disease recurrence compared with group 2 patients who had a 42 % recurrence rate (p = 0.05). Subanalysis of group 2 identified that patients who underwent surgery without evidence of disease did so at a shorter period following the guidelines compared with those who underwent therapeutic surgery (2 ± 2 vs. 16...Continue Reading

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Citations

Jan 9, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ning QuDao-Zhe Lin
Feb 26, 2016·Thyroid : Official Journal of the American Thyroid Association·Ali S AlzahraniHindi Al-Hindi
Jun 18, 2015·Journal of Cellular and Molecular Medicine·Loris BertazzaCaterina Mian
Sep 25, 2014·Annals of Surgical Oncology·Courtney J Balentine, Herbert Chen
Jul 26, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Cristina Garcés VisierJose Lorenzo Alonso Calderón
Sep 17, 2013·The Oncologist·Madhuchhanda RoyRebecca S Sippel
Sep 25, 2019·Cold Spring Harbor Perspectives in Medicine·Jaclyn Schienda, Jill Stopfer
Jan 1, 2014·Expert Review of Endocrinology & Metabolism·Theodora Pappa, Maria Alevizaki
Dec 17, 2014·Molecular Cancer Therapeutics·Renata Jaskula-SztulHerbert Chen
Oct 1, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Andreas KiriakopoulosNikolaos Zavras

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