PMID: 6977644Dec 1, 1981Paper

Hereditary multiple exostoses: report of a kindred

Journal of Medical Genetics
S L GordonR L Ladda

Abstract

In a large family with 37 members with multiple exostoses, only one person has developed sarcomatous degeneration of a lesion. Our review of published reports revealed great variation in the incidence of malignancy in multiple exostoses (10 to 25%). Most studies had sampling errors leading to the apparent overstatement of risk. In large pedigrees with essentially complete ascertainment of affected subjects, the risk of malignancy is nearer 3% or less. This lower risk for malignancy may be more appropriate in counselling affected subjects.

References

Feb 1, 1964·Irish Journal of Medical Science·B MURPHY, J F O'GRADY
Apr 2, 1960·British Medical Journal·J D KNIGHT

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Citations

Jun 1, 1985·Cancer Genetics and Cytogenetics·P A GilmanB G Leventhal
Dec 14, 2011·Pediatric Emergency Care·Dagnachew AssefaArthur B Atlas
Feb 15, 2008·Orphanet Journal of Rare Diseases·Judith V M G Bovée
Jun 26, 2012·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Yoon-Chung KimJung-Woo Lee
Jan 15, 2015·Clinical Orthopaedics and Related Research·Cory M Czajka, Matthew R DiCaprio
Jun 5, 2003·Clinical Orthopaedics and Related Research·Adel Refaat AhmedFranklin H Sim
Nov 26, 1999·Journal of Pediatric Orthopedics·K L CarrollJ C Carey
Feb 14, 2012·Journal of Pediatric Orthopedics·Harpreet ChhinaChristine M Alvarez
Aug 3, 2013·Journal of Pediatric Orthopedics. Part B·Hugh J S PelcGeraint Davies
Nov 19, 2019·Veterinary Surgery : VS·Mario DelcazoFelix Theiss
Jul 9, 1999·The Journal of Pathology·D E Porter, A H Simpson
Apr 27, 2005·The Journal of the American Academy of Orthopaedic Surgeons·Jonathan R Stieber, John P Dormans
Jul 1, 1994·The Journal of Bone and Joint Surgery. American Volume·G A SchmaleW H Raskind
Jul 1, 1996·Clinical Orthopaedics and Related Research·T A DamronK K Unni
Aug 2, 2002·Clinical Orthopaedics and Related Research·K A PierzJ P Dormans

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