PMID: 3750734Jul 1, 1986Paper

Hereditary myopathy in Labrador retrievers: a morphologic study

Veterinary Pathology
R E McKerrell, K G Braund

Abstract

Skeletal muscle and peripheral nerve were obtained over several years from 12 Labrador retrievers with signs of hereditary myopathy. Biopsy and necropsy samples were examined by histology and histochemistry. Despite normal findings in peripheral nerves, a wide range of morphologic changes were observed in muscle including features generally considered characteristic of neurogenic disease. These included small and large muscle fiber group atrophy, presence of small angular fibers, and occasional fiber type grouping. Other prominent changes in muscle were increased numbers of internal nuclei, architectural disturbances, type II fiber deficiency, necrosis, regeneration, and fibrosis--all of which are more usually associated with destructive myopathies or muscular dystrophies. The pathology of this condition, therefore, includes features of both neurogenic and myopathic disease, while the underlying pathophysiology remains unclear.

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Citations

Aug 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alan H BeggsG Diane Shelton
May 1, 1997·The Journal of Small Animal Practice·N J OlbyJ E Houlton
May 1, 1991·Journal of Veterinary Internal Medicine·C T HollandG S Allan
May 23, 2002·Journal of the American Animal Hospital Association·Robert L BergmanG Diane Shelton
Nov 22, 2002·Research in Veterinary Science·T BleyA Jaggy
Feb 8, 2005·Neuromuscular Disorders : NMD·G Diane Shelton, Eva Engvall
Jul 1, 1988·Journal of Veterinary Internal Medicine·A Jaggy, M Vandevelde
Jan 12, 2002·The Veterinary Clinics of North America. Small Animal Practice·Eric N Glass, Marc Kent
Jan 12, 2002·The Veterinary Clinics of North America. Small Animal Practice·Simon R Platt
Oct 12, 2004·The Veterinary Clinics of North America. Small Animal Practice·Simon R Platt, Laurent S Garosi
Oct 12, 2004·The Veterinary Clinics of North America. Small Animal Practice·Scott J Schatzberg, G Diane Shelton
Jan 12, 2002·The Veterinary Clinics of North America. Small Animal Practice·Peter J Dickinson, Richard A LeCouteur
May 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·L A Nafe
May 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·P J Luttgen
May 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·K L Schunk
May 1, 1989·Veterinary Pathology·D R Cordy, T A Holliday
Jan 11, 2011·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Fabio GentiliniFloriana Gernone
Jul 1, 1988·Australian Veterinary Journal·A D WatsonJ B Smyth
Jan 12, 2002·The Veterinary Clinics of North America. Small Animal Practice·G Diane Shelton, Eva Engvall

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