PMID: 9548093Apr 21, 1998Paper

Hereditary non-polyposis colorectal cancer

International Journal of Colorectal Disease
S E GreenJ Burn

Abstract

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant condition in which affected individuals develop colorectal cancer or extracolonic cancers, most commonly endometrial, at an early age. Recent advances in molecular genetics have led to the identification and sequencing of four genes thought to be responsible for the majority of cases of hereditary non-polyposis colorectal cancer. A description of the disease along with details of the underlying genetics and pathological features are presented. Current management and screening policies in these pedigrees are not clearly established. This article discusses some of the controversies in the light of predictive testing.

Citations

Aug 27, 2009·International Journal of Colorectal Disease·Mahsa MolaeiMohammadReza Zali
Mar 1, 2005·Virchows Archiv : an International Journal of Pathology·Pavlína PlevováZdenek Kolár
Oct 13, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R ZhangC-X Li
Sep 4, 2003·Clinical Colorectal Cancer·Henry T LynchRobert Fitzgibbons
Sep 4, 2003·Clinical Colorectal Cancer·Courtney L Scaife, Miguel A Rodriguez-Bigas
Nov 16, 2005·Gastroenterology·Megan HitchinsRobyn Ward
Sep 30, 2000·Assistive Technology : the Official Journal of RESNA·M L CampbellP S Strong
Apr 2, 2002·World Journal of Gastroenterology : WJG·Bo ZhaoYan-Ting Huang
Nov 18, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S AnwarJ B Elder

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