Hereditary Nonpolyposis Colorectal Cancer and Cancer Syndromes: Recent Basic and Clinical Discoveries

Journal of Oncology
Erbao ChenTianshu Liu

Abstract

Approximately one-third of individuals diagnosed with colorectal cancer have a family history of cancer, suggesting that CRCs may result from a heritable component. Despite the availability of current gene-identification techniques, only 5% of all CRCs emerge from well-identifiable inherited causes for predisposition, including polyposis and nonpolyposis syndromes. Hereditary nonpolyposis colorectal cancer represents a large proportion of cases, and robustly affected patients are at increased risk for early onset, synchronous, and metachronous colorectal malignancies and extracolonic malignancies. HNPCC encompasses several cancer syndromes, such as Lynch syndrome, Lynch-like syndrome, and familial colorectal cancer type X, which have remarkable clinical presentations and overlapping genetic profiles that make clinical diagnosis a challenging task. Therefore, distinguishing between the HNPCC disorders is crucial for physicians as an approach to tailor different recommendations for patients and their at-risk family members according to the risks for colonic and extracolonic cancer associated with each syndrome. Identification of these potential patients through epidemiological characteristics and new genetic testing can estimate ...Continue Reading

References

May 1, 1991·Diseases of the Colon and Rectum·H F VasenH T Lynch
Sep 1, 1967·The American Journal of the Medical Sciences·H T LynchA L Larsen
Jul 5, 2001·Gastroenterology·F M GiardielloG M Petersen
Feb 19, 2004·Journal of the National Cancer Institute·Asad UmarSudhir Srivastava
Apr 28, 2005·JAMA : the Journal of the American Medical Association·Noralane M LindorDaniela Seminara
Apr 28, 2005·JAMA : the Journal of the American Medical Association·Hans F A Vasen, C Richard Boland
Aug 9, 2005·Gastroenterology·Heather HampelAlbert de la Chapelle
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lauri AaltonenRichard Houlston
Jan 18, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura ValleMiguel Urioste
Jul 8, 2008·Gastroenterology·Leigha SenterAlbert de la Chapelle
Sep 25, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Steven M TeutschUNKNOWN EGAPP Working Group
Oct 2, 2009·Surgical Oncology Clinics of North America·Noralane M Lindor
Nov 10, 2009·CA: a Cancer Journal for Clinicians·Melissa M CenterElizabeth Ward
Jun 7, 2011·JAMA : the Journal of the American Medical Association·Valérie BonadonaUNKNOWN French Cancer Genetics Network
Jun 12, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zu-Yau Lin, Wan-Long Chuang
Oct 18, 2012·JAMA : the Journal of the American Medical Association·Leticia MoreiraUNKNOWN EPICOLON Consortium
Dec 19, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christina TherkildsenMef Nilbert
Dec 21, 2012·Human Mutation·James G DowtyMark A Jenkins
Jun 20, 2013·Oncology Reports·Hiroshi KobayashiMiyuki Matsuura
Oct 12, 2013·Human Mutation·Nuria SeguíLaura Valle
Jan 29, 2014·Gastroenterology·John M Carethers
Mar 13, 2014·Alimentary Pharmacology & Therapeutics·C Castaño-MillaJ P Gisbert
Jun 24, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Adela CastillejoJosé Luis Soto
Aug 12, 2014·International Journal of Cancer. Journal International Du Cancer·So Young KangKyoung-Mee Kim
Oct 14, 2014·Nature Communications·Eduard SchulzHeinz Sill

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Citations

Sep 16, 2020·Journal of Internal Medicine·R Hultcrantz
Dec 13, 2019·ANZ Journal of Surgery·Steven R ParedesMatthew J F X Rickard
May 26, 2020·BMC Cancer·Karolin BuckschUNKNOWN German Consortium for Familial Intestinal Cancer
Jun 5, 2020·International Journal of Molecular Sciences·Kumar GanesanBaojun Xu
Jan 24, 2021·Medical Oncology·Maria Teresa VietriAnna Maria Molinari
Jun 25, 2021·Frontiers in Oncology·Mahnaz NorouziMohammad Amin Tabatabaiefar
Sep 2, 2021·International Journal of Cancer. Journal International Du Cancer·Karolin BuckschUNKNOWN German Consortium for Familial Intestinal Cancer

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Methods Mentioned

BETA
PCR
GTPase

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