PMID: 8607009Nov 1, 1995Paper

Hereditary nonpolyposis colorectal cancer and colonic adenomas: aggressive adenomas?

Seminars in Surgical Oncology
H T LynchJ R Jass

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) results from an inherited defect in one of the genes responsible for repair of errors that occur during DNA replication. Affected individuals have high risk for cancers of the colon and certain extracolonic sites. It appears that HNPCC patients form adenomas at about the same rate s the general population and there is some circumstantial evidence that adenoma is the precursor to colorectal carcinoma in the syndrome. It is hypothesized that HNPCC features accelerated progression from colonic adenoma to carcinoma, a process theoretically driven by the inability to repair DNA mismatches. Evidence in support of the "Aggressive Adenoma" in HNPCC is provided. We discuss our recommendations for colonoscopic surveillance on an annual basis for HNPCC gene-positive individuals, and for genetic counseling.

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Citations

Feb 28, 2003·The New England Journal of Medicine·Oliver M SieberIan P M Tomlinson
Aug 30, 2008·The American Journal of Surgical Pathology·Alexandros D PolydoridesJoel K Greenson
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