Hereditary nonpolyposis colorectal cancer in young colorectal cancer patients: high-risk clinic versus population-based registry

Gastroenterology
Jonathan P TerdimanYoung S Kim

Abstract

Early onset colorectal cancer (CRC) is an important feature of hereditary nonpolyposis colorectal cancer (HNPCC). We sought to compare rates of genetically defined HNPCC among individuals with early onset CRC drawn from a high-risk clinic and a population-based cancer registry. Probands with CRC diagnosed before 36 years of age were enrolled from a high-risk CRC clinic at the University of California, San Francisco (UCSF), and a population-based Kaiser Permanente (KP) Health Plan cancer registry. Probands provided cancer family histories and tumors for microsatellite instability (MSI) testing and MSH2/MLH1 protein immunostaining. Germline MSH2 and MLH1 mutational analysis was performed. Forty-three probands were enrolled from UCSF and 23 from KP. The UCSF and KP probands had similar median age of onset of CRC (30 vs. 31 years) and the percentage with any personal or family history of another HNPCC-related cancer (70% vs. 74%). However, 28 of 40 (70%) of the UCSF tumors were MSI-H compared with 6 of 18 (33%) of KP tumors (P = 0.01), and 13 germline MSH2 or MLH1 mutations were found in the UCSF group compared with 0 in the KP group (P = 0.0001). In a multivariate analysis, institution (P = 0.002) and the total number of colorecta...Continue Reading

Citations

Apr 3, 2013·Scandinavian Journal of Gastroenterology·Tomas TanskanenLauri A Aaltonen
Jul 19, 2018·Familial Cancer·John Michael O RanolaBrian H Shirts
Feb 19, 2004·Journal of the National Cancer Institute·Asad UmarSudhir Srivastava
Sep 2, 2005·Familial Cancer·Albert de la Chapelle
May 16, 2006·The American Journal of Gastroenterology·Francisco Rodríguez-MorantaUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Apr 11, 2019·Genes, Chromosomes & Cancer·Manuela PinheiroManuel R Teixeira
Sep 3, 2003·Alimentary Pharmacology & Therapeutics·M S GoerresC J J Mulder
Jan 30, 2019·International Journal of Cancer. Journal International Du Cancer·Marina AnteloFrancesc Balaguer
Oct 7, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·María Dolores GiráldezSergi Castellví-Bel
Jun 26, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Richarda M de VoerMarjolijn J L Ligtenberg
Nov 18, 2017·Gastroenterology·Elena M StoffelLaura S Rozek
Feb 16, 2005·La Revue de médecine interne·S OlschwangF Eisinger
Sep 6, 2005·Gastroentérologie Clinique Et Biologique·Catherine Bonaïti-PelliéSylviane Olschwang

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