Hereditary palmoplantar keratoderma (four cases in three generations)

International Journal of Dermatology
Virendra N SehgalS Narayan

Abstract

A 39-year-old man reported with progressive thickening of the skin of the hands and feet and an inability to flex his hand. It was largely asymptomatic; however, brisk walking caused excessive sweating, pain, and widening of the fissures on the soles of the feet. He was unable to walk barefooted. According to his mother, the first episode presented with blistering at 7 days of age. Ever since, the condition has steadily worsened to acquire the current status. He was married at the age of 18 years, and had a stillborn child 18 months afterwards. Presently, he has three children, two girls aged 14 and 12 years and a son aged 10 years. Both the daughters are similarly affected. While cataloguing the details of the pattern of inheritance, the mother of the index case was also found to be affected (Fig. 1). The natural history of the disease was identical. Examination of the palms was marked by pronounced thickening of the skin resulting in the masking of palmar creases. The thickening was well demarcated and its margins were prominent and surrounded by an erythematous halo. The color of the skin was yellow and waxy (Fig. 2a). Contractures were present on all the fingers; nevertheless, the deformity of the middle and distal interpha...Continue Reading

References

Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·P Gamborg NielsenB Lagerholm
Jul 1, 1997·Journal of the American Academy of Dermatology·C M MagroH P Baden
May 20, 1998·Journal of the American Academy of Dermatology·M Z MofidS E Koch
Mar 4, 1999·The Journal of Dermatology·R MaruyamaK Nishioka

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Citations

May 5, 2011·Annals of Plastic Surgery·Elizabeth A O'connor, William W Dzwierzynski
Jun 8, 2021·The Journal of Dermatology·Takahiro HamadaTakekuni Nakama
Jun 15, 2021·The Journal of Dermatology·Kozo YonedaUNKNOWN Committee on Guidelines for the Management of PPKs

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