Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility

Toxicology Letters
J I EverittCheryl L Walker

Abstract

A class of genes, the so-called tumor suppressor genes or anti-oncogenes, was originally identified as being responsible for germ-line transmission of cancer susceptibility in humans. Tumor suppressor genes are recessive at the cellular level with respect to oncogenesis but often manifest as dominantly inherited familial cancer syndromes. This type of cancer syndrome arises in the Eker rat due to a genetic defect in the tuberous sclerosis 2 (Tsc2) gene. The Eker rat familial cancer syndrome serves as a unique animal model in which to study the molecular pathways of renal tubular epithelial carcinogenesis as well as a valuable tool for studies that examine how chemical carcinogens interact with cancer susceptibility genes.

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Citations

Oct 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jianjun WeiKhush Mittal
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·T J JónasdóttirF Lingaas
Jan 25, 2013·Journal of Toxicologic Pathology·Kayoko KudoJohn Curtis Seely
Mar 21, 1998·Toxicologic Pathology·C Walker
Oct 31, 2003·Molecular Carcinogenesis·Sonal K PatelSerrine S Lau
Sep 10, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Todd M KolbMyrtle A Davis
Jul 12, 2002·American Journal of Physiology. Renal Physiology·Hae-Seong YoonSerrine S Lau
Oct 3, 2018·Toxicologic Pathology·Gordon C Hard
Feb 25, 2020·Translational Oncology·Paweł SobczukAnna M Czarnecka

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