Hereditary Spherocytosis Presenting as Diffuse Bone Marrow Activation and Splenomegaly on PSMA-Targeted 18F-DCFPyL PET/CT

Clinical Nuclear Medicine
Erin GomezSteven P Rowe

Abstract

We present the case of a 71-year-old man with Gleason 3 + 3 = 6 pT2N0MxR0 adenocarcinoma of the prostate who presented with rising PSA level 16 years after radical prostatectomy. PSMA-targeted F-DCFPyL PET/CT was performed, which demonstrated recurrent disease in the prostatectomy bed as well as splenomegaly and mild-diffuse bone marrow activation, consistent with the patient's history of hereditary spherocytosis. We briefly review the clinical characteristics of hereditary spherocytosis, its appearance on molecular imaging studies, the normal biodistribution of F-DCFPyL, and the PSMA-RADS scoring system for characterizing findings on PSMA-targeted PET imaging.

References

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Apr 22, 2015·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zsolt SzaboMartin G Pomper
Jun 4, 2017·PET Clinics·Steven P RoweMartin G Pomper
Jun 7, 2017·Seminars in Nuclear Medicine·Wouter van der BruggenRiemer H J A Slart
Aug 3, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Sara SheikhbahaeiSteven P Rowe
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Sep 8, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rudolf A WernerSteven P Rowe
Oct 12, 2018·Annals of Translational Medicine·Olga Ciepiela

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Citations

Feb 29, 2020·Clinical Nuclear Medicine·İpek ArslanNalan Alan Selçuk

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