Aug 31, 2019

Hereditary Tumor Syndromes with Skin Involvement

Dermatologic Clinics
Ramiz N Hamid, Zeynep M Akkurt

Abstract

Cutaneous findings that appear in childhood may be the first sign of a hereditary tumor syndrome. Early detection of genodermatoses allows the patient and at-risk family members to be screened for associated malignancies. This article provides a brief description of the pathogenesis and clinical manifestations of various inherited disorders with skin involvement, along with treatment updates. Advances in molecular-based therapy have spurred development of novel treatment methods for various genodermatoses such as xeroderma pigmentosum (XP) and Gorlin-Goltz syndrome. Further studies are needed to better assess the efficacy of many of these new treatment options.

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Mentioned in this Paper

Basal Cell Nevus Syndrome
Pathogenesis
Neoplastic Syndromes, Hereditary
Description
Malignant Neoplasms
Hereditary Diseases
Molecular Targeted Therapy
Treatment Options

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