Hereditary vascular anomalies: new insights into their pathogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology
J-C Tille, M S Pepper

Abstract

Increased understanding of the mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular malformations. This review focuses on recent advances in our understanding of the mechanisms of angiogenesis/lymphangiogenesis and the differentiation of arterial, venous, and lymphatic vessels. We integrate this knowledge with new data obtained from genetic studies in humans, which have revealed a number of heretofore-unsuspected candidates involved in the development of familial vascular anomalies. We present a common infantile vascular tumor, hemangioma, and then focus on hereditary familial vascular and lymphatic malformations. We also summarize transgenic mouse models for some of these malformations. It seems reasonable to believe that novel therapeutic strategies will soon emerge for the treatment of hemangiomas and vascular malformations.

References

Sep 1, 1992·Clinical and Experimental Dermatology·A H HeagertyT W Robinson
Dec 1, 1992·The British Journal of Dermatology·T MiyamotoS Shimao
Mar 1, 1991·Plastic and Reconstructive Surgery·M RydhC J Dalsgaard
Jan 1, 1990·Progress in Growth Factor Research·R J AkhurstF A Millan
Aug 11, 1988·The New England Journal of Medicine·D RigamontiR F Spetzler
Oct 1, 1970·Archives of Disease in Childhood·O AagenaesR Bjorn-Hansen
Dec 1, 1968·Archives of Disease in Childhood·O AagenaesS Refsum
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M MiettinenI Virtanen
Dec 1, 1983·The Journal of Investigative Dermatology·I M Braverman, A Ken-Yen
Apr 1, 1984·Journal of Medical Genetics·A ShuperI Varsano
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·M GünelR P Lifton
Jul 25, 1995·Nucleic Acids Research·B M HoskingT L Dunn
Oct 5, 1995·The New England Journal of Medicine·A E GuttmacherR I White
Mar 1, 1995·Journal of Medical Genetics·C J GallioneM L Warman
Sep 1, 1994·Human Molecular Genetics·L M BoonM L Warman
Oct 1, 1994·Journal of Cutaneous Pathology·W Y LamP W Allen
Jun 1, 1994·The Journal of Clinical Investigation·K TakahashiR A Ezekowitz
Apr 1, 1994·Clinical Dysmorphology·I K Temple, J R Collin
Jan 1, 1994·Annals of Plastic Surgery·L P TranC R Kaufmann
Aug 1, 1993·Histopathology·C L HebedaT M Starink
Apr 11, 1996·The New England Journal of Medicine·M GunelR P Lifton
Dec 27, 1996·Cell·J Folkman, P A D'Amore
Jan 7, 1998·Journal of the American Academy of Dermatology·L Requena, O P Sangueza
May 13, 1998·British Journal of Plastic Surgery·A IqbalG Scerri
Oct 3, 1998·Trends in Biochemical Sciences·A H ChishtiK B Hoover
Nov 13, 1998·Current Opinion in Lipidology·P LindahlC Betsholtz

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Citations

Jun 17, 2009·Bulletin of Experimental Biology and Medicine·K A PavlovO D Mishnyov
Aug 26, 2009·Bulletin of Experimental Biology and Medicine·K A PavlovO D Mishnyov
Jan 24, 2012·Bulletin of Experimental Biology and Medicine·K A PavlovA I Shchegolev
Jan 26, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Margo McKenna BenoitMichael J Cunningham
Apr 28, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Michael R WardMichael J B Kutryk
Jul 16, 2010·Nature Reviews. Cancer·Axel R PriesTimothy W Secomb
Jul 14, 2005·Current Opinion in Pediatrics·Francine Blei
Mar 22, 2006·Pediatric Research·Chad L Barber, M Luisa Iruela-Arispe
Jun 10, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Nehal M El-RaggalIbrahim S Shaaban
Aug 19, 2008·Radiologic Clinics of North America·Gerald M Legiehn, Manraj K S Heran
May 16, 2009·Neuroimaging Clinics of North America·Isaac C Wu, Darren B Orbach
Mar 20, 2008·Plastic and Reconstructive Surgery·Jugpal S Arneja, Arun K Gosain
Jan 17, 2016·BMC Medical Genetics·Natália BertoniPatricia P Reis
Apr 4, 2017·Experimental Dermatology·Danielle S Wendling-KeimRoland Kappler
Feb 10, 2017·Medical Oncology·Giacomo Colletti, Anna Maria Ierardi
Jun 6, 2019·Journal of Surgical Oncology·A BollettaH C Chen
Apr 4, 2006·The Surgical Clinics of North America·Emily R Christison-Lagay, Steven J Fishman
Jul 19, 2006·The Orthopedic Clinics of North America·Gerald M Legiehn, Manraj K S Heran
Oct 5, 2010·The Journal of Hand Surgery·Benjamin J JacobsJoseph E Imbriglia

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