Abstract
The activation of autocrine loops involving proto-oncogene related receptor tyrosine kinases has led to the analysis of a large number of growth factor systems in human glioma specimens and cell lines. The ErbB-2 system, also called HER-2 or neu, is analogous to the epidermal growth factor receptor system (EGF-R, ErbB-1). Neuregulins consist of a large family of proteins arising from alternative mRNA splicing of a single gene located at 8p22-p11. Activation of ErbB-2 by neuregulins occurs in heterodimeric complexes with ErbB-3 and ErbB-4. A panel of human glioma cell lines, which had previously been analyzed for ErbB-2 expression, was examined for ErbB-3 and ErbB-4 expression. Coordinate expression of ErbB-2, -3 or -4 was not observed in these cell lines. Despite the presence of a complete system capable of signaling in about half the cell lines, no constitutive activation of ErbB-2, -3 or -4 was observed, and autophosphorylation of ErbB-2 in response to heregulin was observed only in one cell line from the panel, NCE-G84. Moreover, the addition of recombinant heregulin or antibodies capable of disrupting ErbB-2/ErbB-3 complexes had no effect on cell proliferation. We conclude that the role of neuregulins and its receptors in t...Continue Reading
Citations
Sep 21, 2004·Journal of Neuroscience Research·Amy K WeaverHarald Sontheimer
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Joanna ReszećZenon Mariak
Jan 27, 2015·Annual Review of Biochemistry·Erika KovacsJohn Kuriyan
Sep 7, 2016·Frontiers in Cell and Developmental Biology·Sean P KennedyDavid R Croucher
Dec 22, 2017·Oncotarget·Mahjabin KhanZhao-Xiang Bian
Aug 26, 2004·British Journal of Cancer·J-F MineoC Berthou
Apr 7, 2005·Glia·Patricia S RitchHarald Sontheimer
Apr 12, 2008·Cancer Gene Therapy·G Sithanandam, L M Anderson
May 3, 2000·Journal of Hematotherapy & Stem Cell Research·S Sinha, S J Corey
Jun 21, 2001·Journal of the National Cancer Institute·G LammeringR K Schmidt-Ullrich
May 17, 2003·Journal of Neuro-oncology·Jörgen CarlssonLars Gedda
Jul 23, 2005·Clinical & Experimental Metastasis·Christophe Stove, Marc Bracke
Oct 4, 2005·Journal of Neuro-oncology·Jean-François MineoChristian Berthou
Mar 25, 2010·Diagnostic Pathology·Sasha GulatiSverre H Torp
Feb 26, 2003·The Journal of Biological Chemistry·Patricia A RitchHarald Sontheimer
Sep 23, 2008·Glia·Ariane SharifVincent Prevot
Jun 16, 2007·Journal of Neuro-oncology·Jean-François MineoPhong Dam Hieu
Jul 4, 2012·Neuro-oncology·Bei LiuGuo-Dong Gao
Dec 29, 2011·Investigational New Drugs·Sharon L LongoDawn E Post
Jun 11, 1999·Journal of Virology·H MileticD von Laer
Feb 14, 2003·Journal of Cell Science·Nikolai N KhodarevRalph R Weichselbaum
Jun 1, 2021·Frontiers in Immunology·Wei-Jiang ZhaoWen-Wen Lin
May 2, 2006·Brain Research Bulletin·Hans-Gert BernsteinBernhard Bogerts