PMID: 9440030Jan 24, 1998Paper

Heregulins and the ErbB-2/3/4 receptors in gliomas

Journal of Neuro-oncology
M WestphalM X Sliwkowski

Abstract

The activation of autocrine loops involving proto-oncogene related receptor tyrosine kinases has led to the analysis of a large number of growth factor systems in human glioma specimens and cell lines. The ErbB-2 system, also called HER-2 or neu, is analogous to the epidermal growth factor receptor system (EGF-R, ErbB-1). Neuregulins consist of a large family of proteins arising from alternative mRNA splicing of a single gene located at 8p22-p11. Activation of ErbB-2 by neuregulins occurs in heterodimeric complexes with ErbB-3 and ErbB-4. A panel of human glioma cell lines, which had previously been analyzed for ErbB-2 expression, was examined for ErbB-3 and ErbB-4 expression. Coordinate expression of ErbB-2, -3 or -4 was not observed in these cell lines. Despite the presence of a complete system capable of signaling in about half the cell lines, no constitutive activation of ErbB-2, -3 or -4 was observed, and autophosphorylation of ErbB-2 in response to heregulin was observed only in one cell line from the panel, NCE-G84. Moreover, the addition of recombinant heregulin or antibodies capable of disrupting ErbB-2/ErbB-3 complexes had no effect on cell proliferation. We conclude that the role of neuregulins and its receptors in t...Continue Reading

Citations

Sep 21, 2004·Journal of Neuroscience Research·Amy K WeaverHarald Sontheimer
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Joanna ReszećZenon Mariak
Jan 27, 2015·Annual Review of Biochemistry·Erika KovacsJohn Kuriyan
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