HERG K+ channel expression in CD34+/CD38-/CD123(high) cells and primary leukemia cells and analysis of its regulation in leukemia cells.

International Journal of Hematology
Huiyu LiShiang Huang

Abstract

The human ether-a-go-go-related (herg) gene encoding K+ channels (HERG) belongs to an evolutionarily conserved multigene family of voltage activated K+ channels. The functional properties of HERG K+ channels are complex and their contribution to the repolarization of the cardiac action potential are well understood. Recent studies revealed that HERG K+ channels are preferentially expressed in different histogenesis of tumor cells. Leukemia is a cancer that originates in the bone marrow hematopoietic stem cells (HSCs). Leukemia stem cells (LSCs) are critical in the perpetuation of the disease. A better understanding of LSCs and molecular biology will allow the design of more effective therapies. We report in this study that herg was expressed in CD34+/CD38-/ CD123(high) LSCs but not expressed in normal bone marrow CD34+/CD38- HSCs. In addtion, herg is also expressed in leukemia cell lines K562 and HL-60 and almost all the primary leukemia cells whereas not in the normal bone marrow cells. In addition, the expression of herg mRNA was not associated with the clinical and cytogenetic feature of leukemia. Moreover, HERG K+ channels can regulate leukemia cells proliferation and cell cycle. These data provide evidence for the oncogeni...Continue Reading

References

Mar 15, 2002·The Journal of Biological Chemistry·Garth A M SmithLyanne C Schlichter
Nov 15, 2002·The Journal of Biological Chemistry·Olivia CrocianiAnnarosa Arcangeli
Mar 24, 2006·Nature·Michael C Sanguinetti, Martin Tristani-Firouzi
Oct 27, 2006·Trends in Cell Biology·Annarosa Arcangeli, Andrea Becchetti

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Citations

Feb 28, 2013·Pflügers Archiv : European journal of physiology·Daniela PalmeStephan M Huber
Mar 6, 2013·Acta Pharmacologica Sinica·Joseph J Babcock, Min Li
Aug 19, 2011·Cell Death & Disease·J JehleD Thomas
Dec 24, 2010·Journal of Gastroenterology and Hepatology·Shenghua JieLi Jiang
May 25, 2011·World Journal of Stem Cells·Gui-Rong Li, Xiu-Ling Deng
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Diana UrregoLuis A Pardo
Dec 20, 2012·Journal of Biomedicine & Biotechnology·Cord Naujokat, Roman Steinhart
Aug 25, 2012·Stem Cells International·Serena Pillozzi, Andrea Becchetti
Jul 8, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H RafieemehrS Shahrabi
May 12, 2020·Frontiers in Pharmacology·Daniela PalmeStephan M Huber
Aug 2, 2018·International Journal of Oncology·Qijiao ChengJingyu Xu
May 4, 2020·International Immunopharmacology·Khadijeh BarzamanLeila Farahmand
Mar 7, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Siyi HeFrancisco S Cayabyab

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