hERG1 channel expression associates with molecular subtypes and prognosis in breast cancer

Cancer Cell International
Jessica IorioElena Lastraioli

Abstract

Breast cancer (BC) is the most frequent malignancy among females worldwide. Despite several efforts and improvements in early diagnosis and treatment, there are still tumors characterized by an aggressive behavior due to unfavorable biology, thus quite difficult to treat. In this view, searching for novel potential biomarkers is mandatory. Among them, in the recent years data have been gathered addressing ion channel as important players in oncology. A retrospective pilot study was performed on 40 BC samples by means of immunohistochemistry in order to evaluate hERG1 potassium channels expression in BC. We provide evidence that hERG1 is expressed in all the BC samples analyzed. hERG1 expression was significantly associated with molecular subtype with the highest expression in Luminal A and the lowest in basal-like tumors (p = 0.001), tumor grading (the highest hERG1 expression in well-moderate differentiated tumors, p = 0.020), estrogen receptors (high hERG1 expression in ER-positive samples, p = 0.008) and Ki67 proliferative index (high hERG1 scoring in samples with low proliferative index, p = 0.038). Also, a p value close to significance was noticed for the association between hERG1 and HER2 expression (p = 0.079). At the su...Continue Reading

References

Dec 31, 2005·Clinical Breast Cancer·Gabriel N HortobagyiUNKNOWN ABREAST Investigators
Dec 6, 2006·Cancer·Emad A RakhaIan O Ellis
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel S ParkerPhilip S Bernard
Jul 31, 2009·BMC Cancer·Divya KhaitanNagendra S Ningaraj
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Aug 18, 2012·PloS One·Martin OeggerliLukas Bubendorf
Aug 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroko MasudaNaoto T Ueno
Aug 24, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A R M WilsonUNKNOWN EUSOMA (European Society of Breast Cancer Specialists)
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal
Dec 4, 2013·Clinical Chemistry·Hong XuSamuel Aparicio
Jan 23, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Olivia CrocianiAnnarosa Arcangeli
Apr 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MalvezziE Negri
Jul 11, 2014·Cancer Biology & Medicine·Danny R YouldenPeter D Baade
Dec 30, 2014·Biochimica Et Biophysica Acta·Elena LastraioliAnnarosa Arcangeli
May 6, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A S CoatesUNKNOWN Panel Members
Jul 3, 2015·The Breast Journal·Shahla Masood
Jul 18, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Annarosa Arcangeli, Andrea Becchetti
Oct 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Bryan A SmithOwen N Witte
Dec 18, 2015·World Journal of Clinical Oncology·Budhi S YadavSwaty Jhamb
Mar 15, 2016·Frontiers in Oncology·Shazia AliMohammad S Jamal
Aug 25, 2016·The New England Journal of Medicine·Fatima CardosoUNKNOWN MINDACT Investigators

❮ Previous
Next ❯

Citations

Mar 3, 2019·Cancers·Clara Serrano-NovilloAntonio Felipe
Jul 25, 2019·Journal of Experimental & Clinical Cancer Research : CR·Hongqiang WangJianling Xia
Feb 23, 2019·Cell Death & Disease·Eun-Kyoung BreuerSaverio Gentile
Sep 24, 2019·Antibodies·Claudia Duranti, Annarosa Arcangeli
Dec 4, 2020·BMC Cancer·Azer FarahBalkiss Bouhaouala-Zahar

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
genotyping

Clinical Trials Mentioned

NCT00433589

Software Mentioned

ONCOTYPE DX
TARGETPRINT
BLUEPRINT
PROSIGNA
Stata
MAMMAPRINT

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Yan Peng
Journal of the National Cancer Institute
Maggie C U CheangTorsten O Nielsen
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
M E Pérez-LópezT García-Caballero
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Johan StaafAke Borg
© 2022 Meta ULC. All rights reserved