Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain

Journal of Medicinal Food
Sun RyuKyung-Ok Cho

Abstract

Versatile biological activities of Hericium erinaceus (HE) have been reported in many brain diseases. However, roles of HE in major psychiatric disorders such as depression and anxiety remain to be investigated. Therefore, we evaluated whether HE could reduce anxiety and depressive behaviors in the adult mouse and its underlying mechanisms. Male C57BL/6 mice were administered HE (20 or 60 mg/kg, p.o.) or saline once a day for 4 weeks. Open field and tail suspension tests were performed 30 min after the last administration of HE, followed by forced swim test 2 days later. We found that chronic administration of HE showed anxiolytic and antidepressant-like effects. To elucidate possible mechanisms, proliferative activity of the hippocampal progenitor cells was assessed by immunohistochemistry of proliferating cell nuclear antigen (PCNA) and Ki67. Moreover, to evaluate neuronal survival in the dentate gyrus, 5-bromo-2'-deoxyuridine (BrdU) (120 mg/kg, i.p.) was given at the first day of HE administration, followed by isolation of the brains 4 weeks later. HE (60 mg/kg) increased the number of PCNA- and Ki67-positive cells in the subgranular zone of the hippocampus, indicating increased proliferation of hippocampal progenitors. In a...Continue Reading

References

Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Feb 26, 2003·European Journal of Pharmacology·Laetitia Prut, Catherine Belzung
Sep 23, 2003·Brain Research·Sita von RichthofenRainer Hellweg
Apr 28, 2004·Trends in Neurosciences·Tracey J Shors
Feb 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Magdalena N JayatissaOve Wiborg
Feb 28, 2006·Biological Psychiatry·Mounira BanasrAnnie Daszuta
Feb 3, 2007·Neurobiology of Disease·Helena FrielingsdorfDonald P Pizzo
Aug 30, 2007·Nature Neuroscience·Amar Sahay, Rene Hen
Feb 2, 2008·Cleveland Clinic Journal of Medicine·Bradley N GaynesMaurizio Fava
Sep 2, 2008·Biological & Pharmaceutical Bulletin·Koichiro MoriNorimichi Nakahata
Oct 17, 2008·Nature·Vaishnav Krishnan, Eric J Nestler
Mar 4, 2009·Molecular Psychiatry·J-M RevestD N Abrous
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte A OomenHarm Krugers
Sep 14, 2010·Biomedical Research·Mayumi NaganoKoichiro Ohnuki
Nov 29, 2012·Nature Neuroscience·Mazen A KheirbekRené Hen
Apr 3, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alexis S HillRené Hen
Oct 21, 2015·Bioorganic & Medicinal Chemistry Letters·Cheng-Chen ZhangJin-Ming Gao
Jan 24, 2016·Neurochemical Research·Chao-Jin XuWei-Lin Jin
Jun 1, 2016·Journal of Asian Natural Products Research·Xu-Li WangGui-Shan Tan
Nov 5, 2016·Cell·J Tiago GonçalvesFred H Gage
Jan 19, 2017·Journal of Medicinal Food·Chia-Wei PhanVikineswary Sabaratnam

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Citations

Dec 29, 2019·International Journal of Molecular Sciences·Pit Shan ChongLee Wei Lim
Feb 20, 2019·International Journal of Molecular Sciences·Hyun-Jong JangKyung-Ok Cho
May 27, 2020·Mini Reviews in Medicinal Chemistry·Sze Yuen LewKah Hui Wong
Jun 3, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Christian Bailly, Jin-Ming Gao
Jul 3, 2021·International Journal of Molecular Sciences·Elisa RodaPaola Rossi
Jul 3, 2018·Neurobiology of Learning and Memory·Ana Raquel Pereira-CaixetaGrace S Pereira

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

GraphPad Prism
SMART

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