Heritability and risks associated with early onset hypertension: multigenerational, prospective analysis in the Framingham Heart Study

BMJ : British Medical Journal
Teemu J NiiranenSusan Cheng

Abstract

Objective To determine the role of early onset versus late onset hypertension as a risk factor for hypertension in offspring and cardiovascular death.Design Multigenerational, prospective cohort study.Setting Framingham Heart Study.Participants Two generations of community dwelling participants with blood pressure measurements performed at serial examinations spanning six decades: 3614 first generation participants with mortality data and 1635 initially non-hypertensive second generation participants with data available on parental blood pressure.Main outcome measures The main outcome measures were relation of parental early onset hypertension (age <55 years) with incidence of hypertension in offspring, using regression analyses, and relation of age at hypertension onset with cause specific mortality using a case (cardiovascular death) versus control (non-cardiovascular death) design.Results In second generation participants, having one or both parents with late onset hypertension did not increase the risk of hypertension compared with having parents with no hypertension; by contrast, the hazard ratios of hypertension were 2.0 (95% confidence interval 1.2 to 3.5) and 3.5 (1.9 to 6.1) in participants with one and both parents wi...Continue Reading

Citations

Oct 13, 2017·Nature Reviews. Cardiology·Charlotte Andersson, Ramachandran S Vasan
Sep 25, 2017·The Journal of Clinical Hypertension·Holly C GoodingLauren E Wisk
Jan 31, 2019·Journal of Developmental Origins of Health and Disease·M A C JansenG W Dalmeijer
Apr 1, 2020·American Journal of Hypertension·Karri SuvilaTeemu J Niiranen
Aug 28, 2020·Current Hypertension Reports·Karri SuvilaTeemu J Niiranen
Mar 28, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Stefano Romeo
Oct 21, 2020·Journal of Human Hypertension·Arttu O LehtonenTeemu J Niiranen
Jan 20, 2021·Hypertension·Karri SuvilaTeemu J Niiranen
Feb 23, 2021·Hypertension·Felix VauraTeemu Niiranen
Mar 19, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Farren Bs BriggsDevon S Conway
Nov 28, 2020·American Journal of Hypertension·Jay D Humphrey
Apr 7, 2021·American Journal of Hypertension·Yuichiro Yano
May 29, 2021·Journal of the American College of Cardiology·Charlotte AnderssonRamachandran S Vasan
Jun 13, 2020·Journal of the American College of Cardiology·Chi WangHao Xue
Jun 13, 2020·Journal of the American College of Cardiology·Teemu J NiiranenSusan Cheng
Jul 22, 2021·Journal of Human Hypertension·Yendelela L CuffeeRobin Taylor Wilson
Apr 28, 2021·American Journal of Hypertension·Karri SuvilaTeemu J Niiranen

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