Heritability of ambulatory and office blood pressure phenotypes in Swedish families

Journal of Hypertension
Cristiano FavaOlle Melander

Abstract

The aim of this study was to estimate the heritability of 24-h ambulatory blood pressure and office blood pressure phenotypes in Swedish families. We measured ambulatory and office blood pressure in 260 siblings without antihypertensive treatment from 118 families. Blood pressure heritability was estimated using standard quantitative genetic variance component analysis implemented in the 'SOLAR' software package after adjustment for significant covariates. Heritability values were significant for night-time systolic (37%), diastolic (32%) and mean (32%) ambulatory blood pressure (P < 0.05 for all). During daytime, systolic ambulatory blood pressure was significantly heritable (33%, P < 0.05). Twenty-four-hour systolic (30%) and diastolic (29%) ambulatory blood pressure also had significant values of heritability (P < 0.05). Pulse pressure ambulatory blood pressure was significantly heritable over 24 h (63%, P < 0.01), during daytime (53%, P < 0.01) and at night (34%, P < 0.05). None of the office blood pressure phenotypes had a significant heritability. We conclude that ambulatory blood pressure, in particular at night, seems better than office blood pressure to capture the heritable part of blood pressure, suggesting that ambu...Continue Reading

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Related Concepts

Family Health Status
Diastolic Blood Pressure
Hypertensive Disease
Antihypertensive Agents
Arterial Stiffness
Blood Pressure
Specialty Type - Ambulatory
Blood Pressure Monitoring, Home
Daytime brand of acetaminophen/dextromethorphan/phenylephrine
Phenotype Determination

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