Heritability of arterial function, fitness, and physical activity in youth: a study of monozygotic and dizygotic twins

The Journal of Pediatrics
Nicola Dominique HopkinsDaniel J Green

Abstract

To examine the role of heredity in determining flow-mediated dilation in young people by comparing conduit artery endothelial function in monozygotic and dizygotic twins. We also determined relationships between physical activity and fitness in each twin subset. Flow-mediated dilation was assessed with high-resolution ultrasonography of the brachial artery in 22 twin pairs (11 monozygotic pairs 13.3 ± 1.6 years, 11 dizygotic pairs 13.6 ± 1.6 years). Fitness was assessed as peak oxygen uptake during an incremental treadmill test. Physical activity was measured with accelerometry. Twin versus twin intraclass correlations were performed for both groups. Flow-mediated dilation was significantly correlated in monozygotic twins only (r = 0.60, P = .02). Heritability of flow-mediated dilation was estimated at 0.44. Total PA time (monozygotic r = 0.77, dizygotic r = 0.60, P < .05) and light physical activity time (monozygotic r = 0.67, dizygotic r = 0.63, P < .05) correlated significantly in both groups. The peak oxygen uptake (r = 0.84, P < .01) was correlated only in monozygotic twins. Genetic factors appear to be responsible for a modest portion of the flow-mediated dilation response, suggesting that flow-mediated dilation can be in...Continue Reading

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Citations

Feb 27, 2013·European Journal of Pediatrics·Emma L HoustonLynne M Boddy
Mar 1, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·B BagattoJ W Hicks
Mar 10, 2016·Games for Health Journal·Melitta A McNarry, Kelly A Mackintosh
Mar 7, 2014·American Journal of Human Biology : the Official Journal of the Human Biology Council·Lynne M BoddyGareth Stratton
Oct 21, 2016·Physiological Genomics·Seung Kyum KimMichael P Massett
Jul 23, 2020·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Michelle V de O BorgesPaulo M S Dantas
Jan 8, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Seung Kyum KimMichael P Massett
Feb 6, 2017·Journal of the American Heart Association·Justin R RyderJulia Steinberger
Dec 10, 2016·Frontiers in Physiology·Seung Kyum Kim, Michael P Massett

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