Heritability of factors of the insulin resistance syndrome in women twins

Genetic Epidemiology
K L EdwardsM A Austin

Abstract

The insulin resistance syndrome (IRS) is characterized by a combination of interrelated coronary heart disease (CHD) risk factors, including low high-density lipoprotein cholesterol (HDL-C) levels, obesity and increases in triglyceride (TG), blood pressure, small low-density lipoprotein particles (LDL), and both fasting and postload plasma insulin and glucose. Using factor analysis, we previously identified 3 uncorrelated factors that explained 66% of the variance among these variables, based on data from women participating in examination 2 of the Kaiser Permanente Women Twins Study in Oakland, CA during 1989-1990. The factors were interpreted as: 1) body mass/fat distribution, 2) insulin/glucose, and 3) lipids: TG, HDL-C, LDL peak particle diameter. In this analysis, heritability of each of the factors was estimated based on data from 140 monozygotic and 96 dizygotic pairs of non-diabetic women twins. Heritability estimates were calculated using the classical approach, the analysis of variance (ANOVA) approach, and the maximum likelihood approach. For the body mass/fat distribution factor heritability estimates suggest moderate genetic influences; 0.61 (P < 0.001), 0.14 (P > 0.05), and 0.71 (P < 0.001), respectively. The insu...Continue Reading

References

Oct 1, 1977·American Journal of Epidemiology·M FeinleibJ O Wagner
Aug 1, 1992·Endocrine Reviews·S I TaylorE Wertheimer
Jul 11, 1992·Computer Methods and Programs in Biomedicine·C J WilliamsJ A Norton
Apr 1, 1992·Diabetes·M C SchumacherS C Elbein
Jan 1, 1991·Genetic Epidemiology·J Blangero, L W Konigsberg
Jan 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M A Austin
Aug 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A LawsG M Reaven
Sep 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M Laakso, E Barrett-Connor
Jan 1, 1989·Behavior Genetics·A C HeathD W Fulker
Jul 4, 1986·JAMA : the Journal of the American Medical Association·A J StunkardZ Hrubec
Jan 1, 1986·Methods in Enzymology·A V NicholsT A Musliner
Mar 1, 1985·The Journal of Clinical Investigation·M ModanZ Fuchs
Jan 23, 1986·The New England Journal of Medicine·A J StunkardF Schulsinger
Dec 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·C M BurchfielK Yano
Aug 1, 1995·The Journal of Clinical Investigation·M CaulfieldA J Clark
Mar 1, 1995·Circulation·R E Dinsmore
Dec 1, 1994·Diabetologia·M I McCarthyM Viswanathan
Dec 1, 1994·Diabetologia·J T CookR C Turner
Dec 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K L EdwardsJ V Selby
Nov 1, 1993·American Journal of Hypertension·R R WilliamsE H Ludwig
May 1, 1993·American Journal of Epidemiology·M Laakso
Jul 1, 1993·The Journal of Clinical Investigation·G M ReavenR M Krauss
Jan 1, 1993·Diabetes·J T CookR C Turner
Apr 22, 1993·The New England Journal of Medicine·D A HellerG E McClearn
Apr 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D L SprecherP M Laskarzewski
May 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M A AustinR M Krauss

❮ Previous
Next ❯

Citations

Apr 5, 2002·Current Atherosclerosis Reports·Braxton D Mitchell, Ikhide G Imumorin
May 21, 2008·Current Atherosclerosis Reports·Tisha Joy, Robert A Hegele
Mar 20, 2003·Current Diabetes Reports·James B Meigs
May 1, 2008·Current Diabetes Reports·Tisha JoyRobert A Hegele
Apr 8, 2006·Current Hypertension Reports·Michèle M SaleBarry I Freedman
Jun 7, 2003·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Katri RäikkönenKristen Salomon
Mar 22, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·M S FreemanP J Grant
Jun 15, 2000·The New England Journal of Medicine·C J HammondC E Gilbert
Jun 8, 2012·Acta Physiologica·J M HagbergE Spangenburg
Aug 10, 2000·The Journal of Clinical Investigation·M P Stern
Feb 21, 2004·BMC Genetics·Lisa J MartinJeff Williams
Jun 16, 2007·The American Journal of the Medical Sciences·Genovefa D KolovouDimitri P Mikhailidis
Sep 14, 2010·Schizophrenia Research·P I Lin, A R Shuldiner
Feb 17, 2009·Metabolism: Clinical and Experimental·Ranjit Mohan AnjanaViswanathan Mohan
Jun 30, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Claudio L LafortunaAlessandro Sartorio
Nov 7, 2006·The Journal of Clinical Hypertension·Annaswamy RajiGordon H Williams
May 23, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giuseppe PennoStefano Del Prato
Oct 28, 2003·Diabetes·Weihong TangUNKNOWN National Heart, Lung, and Blood Institute Family Heart Study
Apr 3, 2004·Journal of Lipid Research·Yohan BosséMarie-Claude Vohl
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A LukeR S Cooper
Aug 26, 2006·Nature Clinical Practice. Cardiovascular Medicine·Rebecca L Pollex, Robert A Hegele
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·K L EdwardsM A Austin
May 3, 2013·Obstetrics and Gynecology·Bas B van RijnArie Franx
Apr 18, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K E NorthJ W MacCluer
Feb 26, 2004·Drugs & Aging·Richard W Grant, James B Meigs
Feb 10, 2007·Psychosomatic Medicine·Jeanne M McCafferyEco de Geus
Aug 16, 2014·Reviews in Endocrine & Metabolic Disorders·Alena Stančáková, Markku Laakso

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.